A Role for the TGF-β/BMP Co-Receptor Endoglin in the Molecular Oscillator That Regulates the Hair Follicle Cycle

    December 2017 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Maria Inmaculada Calvo Sanchez, Elisa Carrasco, Sandra Fernández-Martos … Jesús Espada

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study found that Endoglin is crucial for proper hair follicle cycling and the activation of hair follicle stem cell niches, based on its role in the feedback crosstalk between Wnt/β-catenin and Bmp/Smad signals.
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    Research cited in this study 12

    1. Mouse Hair Cycle Expression Dynamics Modeled as Coupled Mesenchymal and Epithelial Oscillators PLOS Computational Biology · 2014
    2. Emerging Interactions Between Skin Stem Cells and Their Niches Nature Medicine · 2014
    3. Spatial Organization Within a Niche as a Determinant of Stem-Cell Fate Nature · 2013
    4. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012
    5. Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells Science · 2011
    6. Biology and Genetics of Hair Annual Review of Genomics and Human Genetics · 2010
    7. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    8. Analyses of Regenerative Wave Patterns in Adult Hair Follicle Populations Reveal Macro-Environmental Regulation of Stem Cell Activity ˜The œInternational journal of developmental biology · 2009
    9. Complex Hair Cycle Domain Patterns and Regenerative Hair Waves in Living Rodents Journal of Investigative Dermatology · 2007
    10. Scratching the Surface of Skin Development Nature · 2007
    11. Manipulation of Stem Cell Proliferation and Lineage Commitment: Visualization of Label-Retaining Cells in Wholemounts of Mouse Epidermis Development · 2003
    12. Growth of the Hair Physiological Reviews · 1954

    Related research 3

    1. A Role for the TGF-β/BMP Co-Receptor Endoglin in the Molecular Oscillator That Regulates the Hair Follicle Cycle bioRxiv (Cold Spring Harbor Laboratory) · 2017
    2. Ceramide Synthase 4 Regulates Stem Cell Homeostasis And Hair Follicle Cycling Journal of Investigative Dermatology · 2015
    3. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration Cell · 2011