Ceramide Synthase 4 Regulates Stem Cell Homeostasis And Hair Follicle Cycling

    February 2015 in “ Journal of Investigative Dermatology ”
    Franziska Peters, Susanne Vorhagen, Susanne Brodesser … Martin Krönke
    Studysummary This study found that inactivating CerS4 in mice led to hair follicle stem cell exhaustion and hair loss, indicating its role in regulating hair regeneration through ceramide composition and signaling pathways.
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    Research cited in this study 9

    1. Ceramide Synthase 4 Deficiency in Mice Causes Lipid Alterations in Sebum and Results in Alopecia Biochemical Journal · 2014
    2. Competitive Balance of Intrabulge BMP/Wnt Signaling Reveals a Robust Gene Network Ruling Stem Cell Homeostasis and Cyclic Activation Proceedings of the National Academy of Sciences · 2013
    3. A Matter of Life and Death: Self-Renewal in Stem Cells EMBO Reports · 2012
    4. Adenovirus-Mediated Wnt10b Overexpression Induces Hair Follicle Regeneration Journal of Investigative Dermatology · 2012
    5. Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells Science · 2011
    6. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    7. Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin Nature Reviews Molecular Cell Biology · 2009
    8. The Hair Cycle Journal of Cell Science · 2006
    9. Manipulation of Stem Cell Proliferation and Lineage Commitment: Visualization of Label-Retaining Cells in Wholemounts of Mouse Epidermis Development · 2003