Hair Follicle Stem Cell SLC3A2 Regulates Epithelial Regenerative Properties

    September 2025 in “ Journal of Investigative Dermatology ”
    Soline Estrach, Etienne Boulter, Laurence Cailleteau … Chloé C. Féral
    Studysummary This research found that deleting the SLC3A2 gene in hair follicle stem cells disrupts their maintenance and proper differentiation, leading to hair follicle growth defects and altered skin regeneration through a YAP/Taz-dependent pathway.
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    Research cited in this study 15

    1. Epithelial Fibronectin Meshwork Controls Skin Regeneration Journal of Investigative Dermatology · 2025
    2. Sphingolipid Metabolism Orchestrates Establishment Of The Hair Follicle Stem Cell Compartment The Journal of Cell Biology · 2025
    3. YAP/TAZ Signaling Controls Epidermal Keratinocyte Fate International Journal of Molecular Sciences · 2024
    4. Mechanical Forces Across Compartments Coordinate Cell Shape and Fate Transitions to Generate Tissue Architecture Nature cell biology · 2024
    5. Immune-Mediated Alopecias and Their Mechanobiological Aspects Cells and Development · 2022
    6. Symmetry Breaking of Tissue Mechanics in Wound-Induced Hair Follicle Regeneration of Laboratory and Spiny Mice Nature Communications · 2021
    7. Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis Science · 2016
    8. Ceramide Synthase 4 Regulates Stem Cell Homeostasis And Hair Follicle Cycling Journal of Investigative Dermatology · 2015
    9. CD98hc (SLC3A2) Regulation of Skin Homeostasis Wanes With Age ˜The œJournal of experimental medicine/˜The œjournal of experimental medicine · 2013
    10. The Basement Membrane Of Hair Follicle Stem Cells Is A Muscle Cell Niche Cell · 2011
    11. Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin Nature Reviews Molecular Cell Biology · 2009
    12. The Hair Cycle Journal of Cell Science · 2006
    13. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    14. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003
    15. Manipulation of Stem Cell Proliferation and Lineage Commitment: Visualization of Label-Retaining Cells in Wholemounts of Mouse Epidermis Development · 2003