Sphingolipid Metabolism Orchestrates Establishment Of The Hair Follicle Stem Cell Compartment

    January 2025 in “ The Journal of Cell Biology ”
    Franziska Peters, Windie Höfs, Hunki Lee … Sara A. Wickström
    Studysummary This study found that deleting ceramide synthase 4 in skin epidermis stem cells disrupts hair follicle and skin barrier function, leading to immune responses similar to atopic dermatitis, due to imbalances in lipid composition affecting differentiation.
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    Research cited in this study 19

    1. Stem and Progenitor Cells in Sebaceous Gland Development, Homeostasis, and Pathologies Experimental dermatology · 2021
    2. Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle Cell Metabolism · 2020
    3. Murine Epidermal Ceramide Synthase 4 Is a Key Regulator of Skin Barrier Homeostasis Journal of Investigative Dermatology · 2020
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    5. Quiescent Tissue Stem Cells Evade Immune Surveillance Immunity · 2018
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    8. Sebaceous Lipids Are Essential for Water Repulsion, Protection Against UVB-Induced Apoptosis, and Ocular Integrity in Mice Development · 2016
    9. Ceramide Synthase 4 Regulates Stem Cell Homeostasis And Hair Follicle Cycling Journal of Investigative Dermatology · 2015
    10. Emerging Interactions Between Skin Stem Cells and Their Niches Nature Medicine · 2014
    11. Plasticity of Epithelial Stem Cells in Tissue Regeneration Science · 2014
    12. Ceramide Synthase 4 Deficiency in Mice Causes Lipid Alterations in Sebum and Results in Alopecia Biochemical Journal · 2014
    13. In Vivo Transcriptional Governance of Hair Follicle Stem Cells by Canonical Wnt Regulators Nature Cell Biology · 2014
    14. Hair Follicle Mesenchyme-Associated PD-L1 Regulates T-Cell Activation Induced Apoptosis: A Potential Mechanism of Immune Privilege Journal of Investigative Dermatology · 2013
    15. Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin Nature Reviews Molecular Cell Biology · 2009
    16. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    17. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    18. Nfatc1 Balances Quiescence and Proliferation of Skin Stem Cells Cell · 2008
    19. Expression of ΔNLef1 in Mouse Epidermis Results in Differentiation of Hair Follicles into Squamous Epidermal Cysts and Formation of Skin Tumors Development · 2002