Sphingolipid Metabolism Orchestrates the Establishment of the Adult Hair Follicle Stem Cell Niche to Control Skin Homeostasis

    January 2024 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Franziska Peters, Susanne Brodesser, Kai Kruse … Sara A. Wickström

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary In this study, the researchers found that deleting ceramide synthase 4 in the skin's epidermis alters stem cell differentiation, disrupting hair follicle structure and barrier function, potentially leading to immune responses similar to atopic dermatitis.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 15

    1. An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities Frontiers in Cell and Developmental Biology · 2020
    2. Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle Cell Metabolism · 2020
    3. Murine Epidermal Ceramide Synthase 4 Is a Key Regulator of Skin Barrier Homeostasis Journal of Investigative Dermatology · 2020
    4. Signaling in the Stem Cell Niche: Regulating Cell Fate, Function, and Plasticity Development · 2018
    5. Quiescent Tissue Stem Cells Evade Immune Surveillance Immunity · 2018
    6. Hair Follicle Stem Cell Cultures Reveal Self-Organizing Plasticity of Stem Cells and Their Progeny The EMBO Journal · 2016
    7. Sebaceous Lipids Are Essential for Water Repulsion, Protection Against UVB-Induced Apoptosis, and Ocular Integrity in Mice Development · 2016
    8. Ceramide Synthase 4 Regulates Stem Cell Homeostasis And Hair Follicle Cycling Journal of Investigative Dermatology · 2015
    9. Emerging Interactions Between Skin Stem Cells and Their Niches Nature Medicine · 2014
    10. Plasticity of Epithelial Stem Cells in Tissue Regeneration Science · 2014
    11. Ceramide Synthase 4 Deficiency in Mice Causes Lipid Alterations in Sebum and Results in Alopecia Biochemical Journal · 2014
    12. Hair Follicle Mesenchyme-Associated PD-L1 Regulates T-Cell Activation Induced Apoptosis: A Potential Mechanism of Immune Privilege Journal of Investigative Dermatology · 2013
    13. Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin Nature Reviews Molecular Cell Biology · 2009
    14. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    15. Nfatc1 Balances Quiescence and Proliferation of Skin Stem Cells Cell · 2008