Stem and Progenitor Cells in Sebaceous Gland Development, Homeostasis, and Pathologies

March 2021 in “ Experimental dermatology ”

Anna Geueke, Catherin Niemann

TLDR Stem cells are key for the growth, upkeep, and repair of sebaceous glands and for understanding skin disorders.

The document discusses the importance of sebaceous glands (SGs) in maintaining skin health and their role in various skin disorders such as acne, seborrheic dermatitis, and sebaceous tumors. It highlights the progress made in the past two decades in identifying and characterizing skin epithelial stem cells and their contribution to skin homeostasis and pathology. The paper emphasizes recent advances in understanding the cellular mechanisms of SG development, maintenance, and tumor formation, as well as the role of stem and progenitor cells in these processes. It also notes the development of new research tools, including in vivo imaging and various stem cell and SG tissue models, which are expected to enhance mechanistic studies and facilitate drug screening for treating SG-related pathologies.

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