Metabolism and Skin Diseases

    September 2016 in “ Reviews in Endocrine and Metabolic Disorders ”
    Christos C. Zouboulis, Constantine A. Stratakis, George P. Chrousos, Christian A. Koch
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    TLDR Skin health and diseases are closely linked to metabolic processes.
    The document from 2016 explores the significant role of metabolism in skin health and the development of various skin diseases. It explains that the skin is not only a target for hormones but also an active endocrine organ, influencing and being influenced by metabolic processes. The reviews within the document cover a wide range of topics, including the skin's role in hormone production and its implications for conditions such as acne, rosacea, atopic dermatitis, and androgenic alopecia. It also discusses the dermatologic manifestations of growth hormone dysregulation, the effects of diabetes on skin health, and the skin changes associated with Cushing's syndrome. The document examines the brain-skin connection and its implications for dermatoses, the clinical relevance of metabolic pathways in skin diseases like psoriasis and hidradenitis suppurativa, and the potential for new treatments targeting molecular pathways. It also discusses the link between metabolic syndrome and hidradenitis suppurativa, the association of skin diseases with male fertility, and the role of metabolic dysregulation in skin tumor development, obesity, and skin cancer. Additionally, the document reviews the impact of nutrition, environmental factors, and endocrine-disrupting chemicals on skin health and aging, and the challenge of identifying biomarkers for skin aging. The authors conclude by expressing their hope that readers find the thematic issue informative and acknowledge no conflict of interest.
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