Effects of Natural Products on Skin Inflammation Caused by Abnormal Hormones Secreted by the Adrenal Gland

    May 2023 in “ Frontiers in Pharmacology ”
    Wei Xie, Ce Zhang, Tian Wang, Jian‐She Wang, Fenghua Fu
    TLDR Natural products may help treat skin inflammation from abnormal adrenal hormones.
    The review article discusses the impact of natural products on skin inflammation caused by abnormal hormone secretion from the adrenal gland. It highlights that hormones like glucocorticoids, mineralocorticoids, and androgens are crucial for various physiological functions, and their abnormal secretion can lead to skin disorders such as atopic dermatitis, psoriasis, acne, hirsutism, and androgenic alopecia. Natural products, including curcumin, escin, β-carotene, ginsenosides, diosgenin, glycyrrhizic acid, glycyrrhetinic acid, artemisinin, and dihydroartemisinin, have shown potential in reducing skin inflammation by inhibiting pathways like MAPK, PI3K/AKT-dependent NF-κB, and promoting wound healing. These compounds offer promising therapeutic benefits with fewer adverse effects compared to conventional drugs, suggesting potential alternative treatments for skin inflammation caused by hormonal imbalances.
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