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Glossary Cushing's syndrome

condition caused by excessive cortisol, leading to weight gain and skin changes

Cushing's syndrome, also known as hypercortisolism, is a condition characterized by prolonged exposure to high levels of cortisol, a hormone produced by the adrenal glands. This can result from taking corticosteroid medications or from the body producing too much cortisol due to tumors in the pituitary or adrenal glands. Symptoms include weight gain, particularly around the abdomen and face, thinning skin, easy bruising, and in some cases, hair loss or excessive hair growth.

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research Complications of Cushing's syndrome: state of the art

374 citations , May 2016 in “The Lancet. Diabetes & endocrinology”

This article reviews the clinical complications and increased mortality risks associated with Cushing's syndrome but does not present new clinical data; it emphasizes the need for prompt treatment to mitigate these risks.

research Hair Analysis Provides a Historical Record of Cortisol Levels in Cushing's Syndrome

217 citations , July 2009 in “Experimental and Clinical Endocrinology & Diabetes”

This study found that hair cortisol levels were significantly higher in patients with Cushing's Syndrome compared to healthy controls, suggesting hair analysis can provide historical information on cortisol exposure.

research Toward a Diagnostic Score in Cushing's Syndrome

42 citations , November 2019 in “Frontiers in Endocrinology”

This article provides an overview of diagnosing Cushing's syndrome, emphasizing the importance of assessing clinical signs and the appropriate use of first-line biochemical screening.

research Cushing's syndrome due to pharmacological interaction in a cystic fibrosis patient

37 citations , September 2002 in “Acta pædiatrica”

In this study, a patient with cystic fibrosis developed iatrogenic Cushing's syndrome due to impaired clearance of budesonide from concurrent itraconazole use, highlighting the need for regular monitoring in such combination therapies.

research Florid Cushing's Syndrome and Hirsutism Induced by Desoximetasone

25 citations , January 1978 in “JAMA”

This case report describes a 45-year-old woman who developed Cushing's syndrome and hirsutism after using topically applied desoximetasone (Topicorte).

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community There’s nothing better on the horizon [RANT]

22 upvotes 1 month ago

There is skepticism about new hair loss treatments, with the belief that current options like minoxidil, finasteride, and hair transplants are the best available. Concerns are raised about the systemic side effects of androgen-related treatments, even those marketed as topical, and doubts about the effectiveness of emerging treatments like clascoterone.

community How finasteride lowers brain's happiness steroid allopregnanolone and causes depression: systemic dihydroprogesterone crosses blood brain barrier, you don't even need finasteride and brain 5ar for that

288 upvotes 1 year ago

Finasteride may lower allopregnanolone levels, potentially affecting mood, but many users report improved mental health due to reduced hair loss. Experiences with finasteride and dutasteride vary, with some experiencing side effects and others finding them beneficial for hair retention and overall happiness.

community There is something off with DUT and it’s time we stop ignoring it

in Finasteride/Dutasteride 110 upvotes 1 year ago

Dutasteride and finasteride for hair loss, with dissatisfaction expressed about dutasteride and consideration of switching back to finasteride. Users share varied experiences, noting individual responses to treatments differ.

community Husband (35) is thinning on top, he doesn't know yet. Trying to research so he won't feel so lost or upset when I tell him. Help a girl out?

in Research/Science 160 upvotes 1 year ago

A woman is concerned about her husband's hair thinning and researches treatments like finasteride and minoxidil. He decides against medication due to potential side effects and plans to shave his head if necessary.

community I have not seen a single person who claims dutasteride destroyed their hair post a picture of the before/after

in Finasteride/Dutasteride 123 upvotes 2 years ago

The conversation discusses skepticism around claims that dutasteride worsens hair loss, with some users suggesting misinformation or panic during shedding as reasons for such claims. One user shared their negative experience with dutasteride, including increased sebum production and hair loss, and is now considering a higher dose of oral minoxidil after stopping dutasteride.

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