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    GlossaryAdrenal-Dependent Hyperadrenocorticism

    condition where adrenal tumors cause excessive cortisol production

    Adrenal-Dependent Hyperadrenocorticism (ADH), also known as adrenal-dependent Cushing's syndrome, is a condition where the adrenal glands produce excessive amounts of cortisol due to a tumor in one or both adrenal glands. This overproduction of cortisol can lead to symptoms such as weight gain, thinning skin, hair loss, and high blood pressure.

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      a synthetic cortisol used for anti-inflammatory effects

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      community Sugar and Hair loss connections

      in Research/Science  43 upvotes 1 week ago
      High sugar diets may worsen hair loss by increasing 5α-reductase activity and androgen levels, especially in women with PCOS. A low sugar diet might reduce scalp DHT levels, similar to finasteride, but genetics also significantly influence hair loss.

      community Bile Acid-Mediated DHT Dysregulation Hypothesis

      in Research/Science  13 upvotes 6 months ago
      Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.

      community DHT and 5AR respect post, it's importance within the brain

      in Research/Science  111 upvotes 1 year ago
      The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.