Hyperadrenocorticism Associated With Sex Steroid Excess

    Deborah S. Greco
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    TLDR Dogs with sex hormone imbalances may not drink or pee a lot but often lose hair on their body and can have reproductive system issues.
    The document from 2007 discusses the diagnosis of sex steroid excess or hyperadrenocorticism in dogs, which can be difficult due to its varied manifestations that differ from standard hyperadrenocorticism. Unlike typical cases, dogs with sex steroid imbalance often do not show signs of polydipsia and polyuria but may present with trunkal hair loss, particularly in certain breeds like miniature poodles. Additionally, reproductive system involvement is common, with neutered male or female dogs developing perianal adenomas. Laboratory findings frequently indicate elevated serum alkaline phosphatase and serum alanine transferase levels. The article reviews the causes, typical characteristics, clinical signs, and lab findings of atypical hyperadrenocorticism due to sex steroid imbalance and discusses medical, surgical, and radiation treatment options.
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