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GlossaryAdrenal Insufficiency (Addison's disease)

occurs when adrenal glands produce insufficient cortisol and aldosterone

Adrenal Insufficiency, also known as adrenal failure or adrenal hypofunction, is a condition where the adrenal glands do not produce enough of certain hormones, particularly cortisol and sometimes aldosterone. This can lead to symptoms such as fatigue, muscle weakness, weight loss, low blood pressure, and skin changes. It can be caused by autoimmune disorders, infections, or other underlying health issues, and requires medical diagnosis and management.

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research Autoimmune Polyglandular Syndrome Type 2 Presentation With Alopecia Universalis, Hashimoto's Disease, and Addison's Disease

June 2025 in “International Medical Case Reports Journal”

Timely diagnosis and treatment of complex autoimmune diseases like APS2 are crucial to prevent complications and improve life quality.

research Screening for Associated Autoimmune Disorders in Polish Patients with Addison’s Disease

43 citations, March 2010 in “Endocrine”

research Histopathologic Findings of Cutaneous Hyperpigmentation in Addison's Disease and Immunostain of the Melanocytic Population

9 citations, June 2017 in “The American journal of dermatopathology/American journal of dermatopathology”

The study found increased skin pigmentation and variable melanocyte density in a patient with Addison's disease.

research Cutaneous Manifestations of Endocrine-Metabolic Disease and Nutritional Deficiency in the Elderly

18 citations, January 2004 in “Dermatologic Clinics”

Skin problems in older people can indicate hormonal diseases, nutritional deficiencies, or conditions like diabetes, menopause, and HIV.

research Skin Diseases Due to Endocrine Alterations

16 citations, January 2006 in “The Aging Male”

Hormone imbalances can cause skin diseases, and understanding these links is important for diagnosis and treatment.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 11 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.