Neuroimmunoregulation of Androgens in the Adrenal Gland and the Skin

Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.

A 20-year-old female is using finasteride 5mg and spironolactone 100mg for severe hirsutism and is experiencing minor side effects like water weight loss and irregular periods. She is concerned about potential future side effects and hair regrowth on her scalp.

The user experienced side effects from minoxidil, including hirsutism and facial changes, and switched to castor oil, which has not caused similar side effects. They continue using microneedling and dutasteride, reporting minor hair shedding but no significant hair loss.

A user experienced hair shedding after stopping and restarting topical minoxidil due to side effects like facial edema and hirsutism. They are considering alternatives like low-dose oral minoxidil, PRP, and red light therapy, while others suggest finasteride and caution against combining multiple treatments without medical advice.

Follicopeptide (FOL005) by Coegin Pharma will launch as a cosmetic hair growth treatment by Q2 2025, showing similar efficacy to finasteride. Users discuss the benefits and skepticism of releasing hair loss treatments as cosmetics rather than drugs.

The user experiencing diffuse hair loss is using various treatments including RU58841, finasteride, minoxidil with tretinoin, anti-hair loss shampoo, and microneedling, and is considering adding peptides TB500, BPC157, and GHK-Cu. They have low growth hormone levels and are questioning its impact on hair loss, while another user suggests androgenic alopecia and androgens are likely the main cause of hair loss.