Blimp1+ Cells Generate Functional Mouse Sebaceous Gland Organoids In Vitro

May 2019 in “ Nature communications ”

Alona Feldman, Dzmitry Mukha, Itzhak I. Maor, Egor Sedov, Elle Koren, Yahav Yosefzon, Tomer Shlomi, Yaron Fuchs

Blimp1+ cells sebaceous gland organoids sebocytes c-Myc acne vulgaris sebaceous gland acne

TLDR Single Blimp1+ cells can create functional sebaceous gland organoids in the lab.

Researchers demonstrated that single Blimp1+ cells from mice could generate functional sebaceous gland (SG) organoids in vitro, mimicking SG homeostasis. These organoids had an outer layer of proliferating cells that migrated inward and differentiated into lipid-filled sebocytes. Using confocal microscopy and mass spectrometry, the organoids showed markers and a lipidomic profile similar to in vivo SGs. The study also identified c-Myc's role in sebocyte proliferation and differentiation, suggesting that SG organoids could be used to study acne vulgaris and identify therapeutic targets.

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