Blimp1+ Cells Generate Functional Mouse Sebaceous Gland Organoids In Vitro

    May 2019 in “ Nature communications ”
    Alona Feldman, Dzmitry Mukha, Itzhak I. Maor … Yaron Fuchs
    Studysummary This study found that Blimp1+ cells from mice can generate sebaceous gland organoids in vitro, which mimic natural gland traits and may aid in studying acne vulgaris.
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    Research cited in this study 15

    1. Host-Microbiome Interactions and Recent Progress in Understanding the Biology of Acne Vulgaris Microbiome · 2018
    2. Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size Molecular Cell · 2018
    3. Isolation of Stem Cells and Progenitors from Mouse Epidermis Current Protocols in Stem Cell Biology · 2017
    4. Hair Follicle Stem Cell Cultures Reveal Self-Organizing Plasticity of Stem Cells and Their Progeny The EMBO Journal · 2016
    5. Isolating Hair Follicle Stem Cells and Epidermal Keratinocytes from Dorsal Mouse Skin Journal of Visualized Experiments · 2016
    6. BLIMP1 Is Required for Postnatal Epidermal Homeostasis but Does Not Define a Sebaceous Gland Progenitor Under Steady-State Conditions Stem cell reports · 2014
    7. Plasticity of Epithelial Stem Cells in Tissue Regeneration Science · 2014
    8. Ligand-Independent Epidermal Growth Factor Receptor Hyperactivation Increases Sebaceous Gland Size and Sebum Secretion in Mice Experimental Dermatology · 2013
    9. Sept4/ARTS Regulates Stem Cell Apoptosis and Skin Regeneration Science · 2013
    10. C-MYC-Induced Sebaceous Gland Differentiation Is Controlled by an Androgen Receptor/p53 Axis Cell reports · 2013
    11. Development and Homeostasis of the Sebaceous Gland Seminars in Cell & Developmental Biology · 2012
    12. Scratching the Surface of Skin Development Nature · 2007
    13. Bone Morphogenetic Protein Signaling Regulates Postnatal Hair Follicle Differentiation and Cycling ˜The œAmerican journal of pathology · 2004
    14. Deregulated Expression of c-Myc Depletes Epidermal Stem Cells Nature Genetics · 2001
    15. C-Myc Activation in Transgenic Mouse Epidermis Results in Mobilization of Stem Cells and Differentiation of Their Progeny Current Biology · 2001

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    4. Characterization of Hair Follicle Development in Engineered Skin Substitutes PLOS ONE · 2013
    5. Development and Homeostasis of the Skin Epidermis Cold Spring Harbor perspectives in biology · 2012
    6. Histomorphological Studies on the Skin of Camel (Camelus Dromedarius) in Bangladesh Bangladesh Journal of Animal Science · 1992