CD98hc (SLC3A2) Regulation of Skin Homeostasis Wanes With Age

    January 2013 in “ ˜The œJournal of experimental medicine/˜The œjournal of experimental medicine ”
    Etienne Boulter, Soline Estrach, Aurélia Errante, Catherine Pons, Laurence Cailleteau, Floriane S. Tissot, Guerrino Meneguzzi, Chloé C. Féral
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    TLDR CD98hc's role in skin health decreases with age.
    The study investigated the role of CD98hc (SLC3A2) in skin homeostasis and aging. It found that CD98hc deletion in murine epidermis led to improper skin homeostasis and wound healing, resembling aged skin alterations. These defects were linked to reduced CD98hc expression in elderly mice and were associated with early integrin-dependent Src activation issues. The study highlighted the importance of the CD98hc/integrins/RhoGEF (LARG)/RhoA pathway in maintaining skin homeostasis and showed that deregulated RhoA activation in the absence of CD98hc was due to impaired amino acid transport.
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