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research Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria

308 citations , December 2018 in “PLOS Genetics”

This study identified three novel genetic loci associated with PCOS and found similar genetic architecture across different diagnostic criteria, with evidence suggesting genetic links between PCOS and various metabolic and psychological traits.

research Large doses of glucocorticoid in the treatment of alopecia areata

80 citations , November 1975 in “Acta dermato-venereologica”

This study found that while some patients with severe alopecia areata responded to high-dose prednisolone, the response was inconsistent and the therapy's risks prevent recommending it for general use.

research Large Scale Gene Expression Profiles of Regenerating Inner Ear Sensory Epithelia

77 citations , June 2007 in “PLoS ONE”

This study identified changes in transcription factor gene expression across various signaling pathways during inner ear hair cell regeneration in birds, revealing patterns and potential new pathways for future investigation.

research Large-scale cultivation of transplantable dermal papilla cellular aggregates using microfabricated PDMS arrays

25 citations , August 2010 in “Acta Biomaterialia”

This study achieved a first by successfully forming large quantities of dermal papilla spheroidal microtissues, which retained their hair induction potential, using a micropatterned culture system.

research Large Screening Identifies ACE2 Positively Correlates With NF-κB Signaling Activity and Targeting NF-κB Signaling Drugs Suppress ACE2 Levels

13 citations , November 2021 in “Frontiers in Pharmacology”

This study found that Cepharanthine and Glucosamine significantly inhibited ACE2 levels and related inflammatory pathways in human cell lines, suggesting potential inhibitory effects during SARS-CoV-2 infection.

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Community Join

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community Considering Hair Transplant for Natural Widow’s Peak and Large Forehead

in General 29 upvotes 11 months ago

The conversation discusses whether someone with a naturally large forehead and widow's peak can get a hair transplant and start finasteride early. It also mentions a surgery to lower the hairline as an alternative.

community Why did this recent research paper from professor Tsuji lab in Japan largely go unnoticed by this sub? Isn't this discovery huge? (hair cloning)

35 upvotes 4 months ago

A recent discovery in hair cloning identified a previously unknown cell type essential for hair follicle growth, which could potentially make lab-grown hair viable if translated to humans. However, skepticism remains due to past delays and the challenges of replicating results in humans and making the process affordable.

community He used Dutasteride for 20 YEARS: TL;DR Slight gains and largely stable for 20 years.

25 upvotes 2 years ago

John has experienced slight hair gains and stability over 20 years using Dutasteride, which is more effective than Finasteride in reducing scalp DHT and maintaining hair. Dutasteride at 0.5mg daily has a similar side effect profile to Finasteride, but at higher doses, it may increase the risk of sexual side effects.

community Topical Minoxidil since April 2025. Finasteride since Sept 2025. Bald spot has gotten larger in area size and more noticeable in recent months. Trying to be patient but situation doesn’t seem to be resolving

7 upvotes 11 months ago

The user has been using topical Minoxidil since April 2025 and Finasteride since September 2025, but their bald spot has worsened. They are considering switching to oral Minoxidil and have been advised to be patient, see a dermatologist, and possibly try additional treatments like derma rolling.

community Out of curiosity, why are Finasteride pills formulated as small tablets, while Dutasteride pills are much larger soft gel capsules?

in Finasteride/Dutasteride 41 upvotes 1 year ago

Finasteride and Dutasteride are used for hair loss, with Dutasteride often in gel form for better bioavailability. Switching from Finasteride to Dutasteride is common, with some users combining treatments like Minoxidil for improved results.

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Learn

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learn Scalp Micropigmentation

Can scalp micropigmentation work for long hair? Providers say SMP can add the look of density under longer hair, but most say it works best with short hair, and results vary.
How should you care for your scalp after Scalp Micropigmentation to keep the results looking natural? Avoid sweating, sun exposure, and washing for 3-7 days after scalp micropigmentation.
Can scalp micropigmentation hide my scars? Providers say SMP can make scalp scars much less visible, but not invisible; this is a provider claim, not a measured result.

learn Hair Transplant

Which hair transplant method is better: FUE or DHI? Both are FUE-based methods. Clinics make competing claims about precision, density and speed, but no published comparative trial shows either gives better results.

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