YAP/TAZ Signaling Controls Epidermal Keratinocyte Fate

The review discusses the critical role of YAP and TAZ signaling in controlling the fate of epidermal keratinocytes (KCs), emphasizing their influence on proliferation, differentiation, and response to injury. YAP and TAZ are key components of the Hippo pathway and interact with various signaling pathways, such as WNT/β-catenin, SHH, and EGF/EGFR, to regulate KC behavior. Their nuclear localization is associated with KC proliferation, while cytoplasmic localization is linked to differentiation. Overactivation of YAP/TAZ leads to hyperproliferation and disrupted differentiation, contributing to conditions like psoriasis and alopecia, whereas their inhibition results in thinner skin and hair loss. The study underscores the importance of YAP/TAZ in maintaining epidermal homeostasis and their potential as therapeutic targets for skin diseases and enhancing wound healing.