YAP/TAZ Signaling Controls Epidermal Keratinocyte Fate

    November 2024 in “ International Journal of Molecular Sciences ”
    M. D. Pankratova, Andrei Riabinin, Elizaveta A. Butova, Arseniy V. Selivanovskiy, Elena I. Morgun, Sergey V. Ulianov, Е. A. Vorotelyak, Ekaterina P. Kalabusheva
    Studysummary This review summarizes existing evidence on how YAP and TAZ proteins are activated in epidermal keratinocytes and their role in coordinating with other signaling molecules to control transcription and influence epidermal cell fate, highlighting their importance beyond the Hippo pathway. Our plain-language summary of this paper — not a Tressless recommendation.
    The review discusses the critical role of YAP and TAZ signaling in controlling the fate of epidermal keratinocytes (KCs), emphasizing their influence on proliferation, differentiation, and response to injury. YAP and TAZ are key components of the Hippo pathway and interact with various signaling pathways, such as WNT/β-catenin, SHH, and EGF/EGFR, to regulate KC behavior. Their nuclear localization is associated with KC proliferation, while cytoplasmic localization is linked to differentiation. Overactivation of YAP/TAZ leads to hyperproliferation and disrupted differentiation, contributing to conditions like psoriasis and alopecia, whereas their inhibition results in thinner skin and hair loss. The study underscores the importance of YAP/TAZ in maintaining epidermal homeostasis and their potential as therapeutic targets for skin diseases and enhancing wound healing.
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