Thy1-Mediated Mechanisms Converge to Drive YAP Activation in Skin Homeostasis and Repair

The study explored the role of THY1 in skin homeostasis and repair, particularly its effect on YAP activation. Researchers found that Thy1-/- mice showed an increase in hair follicles and enhanced YAP activation, which improved skin repair and regeneration. Various experiments, including immunofluorescence, qPCR, and immunoblotting, were conducted on both wild type and Thy1-/- mice, as well as cultured keratinocytes. The results indicated that the absence of THY1 led to increased cell adhesion and proliferation, thereby enhancing wound healing. The study suggested that targeting THY1-mediated pathways could be a promising therapeutic strategy for skin repair.