Hair Follicle Stem Cells: The Signaling Hub of the Skin

January 2024 in “ Journal of cellular immunology ”

Yue‐Qiu Tan, Haocai Chang

hair follicle stem cells HFSCs Wnt/β-catenin TGFβ/BMP Notch Hedgehog bulge region outer root sheath skin homeostasis niche cells stem cells Wnt signaling TGF-beta BMP Notch signaling Hedgehog signaling

TLDR Hair follicle stem cells are important for maintaining healthy skin and interact with many signals.

Hair follicle stem cells (HFSCs) are multipotential with a high proliferative capacity and play a crucial role in skin homeostasis through complex signaling pathways such as Wnt/β-catenin, TGFβ/BMP, Notch, and Hedgehog. Located in the bulge region of the hair follicle's outer root sheath, HFSCs act as a central hub for skin-organizing signals, interacting with other specialized niche cells. This review highlights the detailed interactions of cell-intrinsic and cell-extrinsic factors that regulate HFSCs, aiming to enhance the understanding of skin disorders and support future research in this area.

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