Hair Follicle Stem Cells: The Signaling Hub of the Skin

    January 2024 in “ Journal of cellular immunology ”
    Yue‐Qiu Tan, Haocai Chang
    Image of study
    TLDR Hair follicle stem cells are important for maintaining healthy skin and interact with many signals.
    Hair follicle stem cells (HFSCs) are multipotential with a high proliferative capacity and play a crucial role in skin homeostasis through complex signaling pathways such as Wnt/β-catenin, TGFβ/BMP, Notch, and Hedgehog. Located in the bulge region of the hair follicle's outer root sheath, HFSCs act as a central hub for skin-organizing signals, interacting with other specialized niche cells. This review highlights the detailed interactions of cell-intrinsic and cell-extrinsic factors that regulate HFSCs, aiming to enhance the understanding of skin disorders and support future research in this area.
    Discuss this study in the Community →