Comprehensive Analysis of LncRNA AC010789.1 Delays Androgenic Alopecia Progression by Targeting MicroRNA-21 and the Wnt/β-Catenin Signaling Pathway in Hair Follicle Stem Cells

    February 2022 in “ Frontiers in Genetics
    Jiachao Xiong, Bao-jin Wu, Qiang Hou, Xin Huang, Lingling Jia, Yufei Li, Hua Jiang
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    TLDR The LncRNA AC010789.1 slows down hair loss by promoting hair follicle growth and interacting with miR-21 and the Wnt/β-catenin pathway.
    The study investigates the role of LncRNA AC010789.1 in the progression of Androgenic Alopecia (AGA), a common type of hair loss. The research found that AC010789.1 expression was downregulated in AGA scalp tissues. Overexpression of AC010789.1 promoted the proliferation and differentiation of Hair Follicle Stem Cells (HFSCs), which are crucial for hair follicle regeneration. AC010789.1 delays AGA progression by interacting with miR-21 and activating the Wnt/β-catenin signaling pathway. The study involved the analysis of gene expression data from five individuals with AGA and adjacent normal scalp tissues, revealing 198 differentially expressed genes (DEGs). Further analysis identified 11 common genes that were targeted by both AC010789.1 and miR-21. The findings provide new insights into the mechanisms by which AC010789.1 promotes the proliferation and differentiation of HFSCs, potentially paving the way for the development of lncRNA-based AGA therapies.
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