Vascular Endothelial Growth Factor Protects CD200-Rich and CD34-Positive Hair Follicle Stem Cells Against Androgen-Induced Apoptosis Through the Phosphoinositide 3-Kinase/Akt Pathway in Patients With Androgenic Alopecia

September 2019 in “ Dermatologic Surgery ”

Xuesong Zhang, Dongmei Zhou, Tengfei Ma, Qingquan Liu

Vascular Endothelial Growth Factor CD200-rich hair follicle stem cells CD34-positive hair follicle stem cells androgen-induced apoptosis Phosphoinositide 3-Kinase/Akt pathway androgenic alopecia VEGF HFSCs PI3K/Akt pathway AGA

TLDR A substance called Vascular Endothelial Growth Factor can protect certain hair follicle stem cells from damage caused by androgens, suggesting a new possible treatment for hair loss.

In a 2020 study involving 15 male patients with Androgenic Alopecia (AGA), researchers found that Vascular Endothelial Growth Factor (VEGF) can protect CD200-rich and CD34-positive hair follicle stem cells (HFSCs) from androgen-induced apoptosis via the PI3K/Akt pathway. The protective effect of VEGF was dose-dependent, with the most effective dose being 200 ng/mL. The study suggested that using VEGF to protect these specific HFSCs could be a potential new therapeutic strategy for AGA.

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