Co-Expression Pattern of VEGFR-2 With Indicators Related to Proliferation, Apoptosis, and Differentiation of Anagen Hair Follicles

January 2023 in “ Open Life Sciences ”

Ru Dai, Qi Xu, Zewei Shao, Xianjie Wu

VEGFR-2 vascular endothelial growth factor receptor-2 anagen hair follicles β-catenin Bcl-2 involucrin AE13 hair cortex cytokeratin keratin 14 keratin 16 Laminin 5 VEGF receptor-2 hair growth phase beta-catenin B-cell lymphoma 2 hair differentiation protein hair cortex protein basement membrane protein

Studysummary This study found that VEGFR-2 activation may play a role in hair follicle differentiation, proliferation, and apoptosis by co-expressing with several key proteins in normal human scalp skin.

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The study investigated the role of VEGF receptor-2 (VEGFR-2) in hair follicle development by examining its co-expression with various indicators of proliferation, apoptosis, and differentiation in anagen hair follicles of normal human scalp skin. Using immunofluorescence double staining, the researchers found a strong overlapping expression pattern of VEGFR-2 with β-catenin and Bcl-2, which are associated with cell proliferation and anti-apoptosis, respectively. Additionally, VEGFR-2 showed associated expression patterns with involucrin, AE13 (hair cortex cytokeratin), keratin 14, keratin 16, and Laminin 5, which are related to hair follicle differentiation. These findings suggest that VEGFR-2 activation may be involved in the processes of differentiation, proliferation, and apoptosis of hair follicles in vivo.

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