The Glypican-1/HGF/C-Met and Glypican-1/VEGF/VEGFR2 Ternary Complexes Regulate Hair Follicle Angiogenesis

December 2021 in “ Frontiers in cell and developmental biology ”

Charlie Colin-Pierre, Nicolas Berthélémy, Nicolas Belloy, Louis Danoux, Vincent Bardey, Romain Rivet, Solène Mine, Christine Jeanmaire, François‐Xavier Maquart, Laurent Ramont, Stéphane Brézillon

glypican-1 GPC1 angiogenesis hair follicles alopecia human dermal microvascular endothelial cells HDMEC keratinocytes outer root sheath KORS vascular endothelial growth factor VEGF hepatocyte growth factor HGF VEGFR2 c-Met receptors microvascularization c-Met

Studysummary This study found that GPC1 is a crucial regulator of angiogenesis in human dermal microvascular endothelial cells, indicating its potential as a target for treating alopecia.

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