Integral Roles of Specific Proteoglycans in Hair Growth and Hair Loss: Mechanisms Behind the Bioactivity of Proteoglycan Replacement Therapy with Nourkrin with Marilex in Pattern Hair Loss and Telogen Effluvium

    Jan Wadstein, Erling Thom, A. G. Gadzhigoroeva
    Studysummary This review discusses "follicular hypoglycania" as a potential pathology in hair growth disorders and reports that proteoglycan replacement therapy may improve hair loss treatments, though it presents no new clinical trial results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on downloads.hindawi.com →
    Discuss this study in the Community →

    Research cited in this study 53

    1. Alopecia Areata and the Gut: The Link Opens Up for Novel Therapeutic Interventions Expert Opinion on Therapeutic Targets · 2018
    2. Autophagy Is Essential for Maintaining the Growth of a Human Mini-Organ: Evidence from Scalp Hair Follicle Organ Culture PLOS Biology · 2018
    3. Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2017
    4. Androgens and Androgen Receptor Action in Skin and Hair Follicles Molecular and Cellular Endocrinology · 2017
    5. Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia Through Overgrowth of Lactobacillus Murinus in Mice Cell Reports · 2017
    6. Oxidative Stress in Androgenetic Alopecia PubMed · 2017
    7. Pregnancy and the Hair Growth Cycle: Anagen Induction Against Hair Growth Disruption Using Nourkrin with Marilex, a Proteoglycan Replacement Therapy Journal of Cosmetic Dermatology · 2016
    8. Interventions for Female Pattern Hair Loss The Cochrane library · 2016
    9. Advances in Understanding Hair Growth F1000Research · 2016
    10. Isolation and Quantification of Glycosaminoglycans from Human Hair Shaft Annals of Dermatology · 2016
    11. A Guide to Studying Human Hair Follicle Cycling In Vivo Journal of Investigative Dermatology · 2015
    12. The Androgen Receptor Antagonizes Wnt/β-Catenin Signaling in Epidermal Stem Cells Journal of Investigative Dermatology · 2015
    13. Oxidative Stress-Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia Journal of Investigative Dermatology · 2015
    14. Telogen Effluvium: A Review Journal of Clinical and Diagnostic Research · 2015
    15. A Newly Discovered Linkage Between Proteoglycans and Hair Biology: Decorin Acts as an Anagen Inducer Experimental Dermatology · 2014
    16. Androgen Receptor Accelerates Premature Senescence of Human Dermal Papilla Cells in Association with DNA Damage PLOS ONE · 2013
    17. Cause of Androgenic Alopecia Plastic and reconstructive surgery. Global open · 2013
    18. Hair Follicle Signaling Networks: A Dermal Papilla–Centric Approach Journal of Investigative Dermatology · 2013
    19. Thyroid Hormone Action on Skin Current Opinion in Endocrinology, Diabetes and Obesity · 2012
    20. Interventions for Female Pattern Hair Loss Cochrane Database of Systematic Reviews · 2012
    21. The Human Hair Follicle, A Bistable Organ? Experimental Dermatology · 2012
    22. Dihydrotestosterone-Inducible IL-6 Inhibits Elongation of Human Hair Shafts by Suppressing Matrix Cell Proliferation and Promotes Regression of Hair Follicles in Mice Journal of Investigative Dermatology · 2011
    23. Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla Journal of Dermatological Science · 2010
    24. Female Pattern Hair Loss: Beyond an Androgenic Aetiology? British Journal of Dermatology · 2010
    25. Female Pattern Hair Loss in Complete Androgen Insensitivity Syndrome British Journal of Dermatology · 2010
    26. Is There a Gut-Brain-Skin Axis? Experimental Dermatology · 2010
    27. Cutaneous Consequences of Inhibiting EGF Receptor Signaling In Vivo: Normal Hair Follicle Development, But Retarded Hair Cycle Induction and Inhibition of Adipocyte Growth in EgfrWa5 Mice Journal of Dermatological Science · 2010
    28. Androgenetic Alopecia in Males: A Histopathological and Ultrastructural Study Journal of Cosmetic Dermatology · 2009
    29. Keratinocyte Growth Inhibition Through the Modification of Wnt Signaling by Androgen in Balding Dermal Papilla Cells ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2009
    30. Nourkrin: Objective and Subjective Effects and Tolerability in Persons with Hair Loss Journal of International Medical Research · 2006
    31. Biology of the Hair Follicle: The Basics Seminars in Cutaneous Medicine and Surgery · 2006
    32. Natural Scalp Hair Regression in Preclinical Stages of Male Androgenetic Alopecia and Its Reversal by Finasteride Skin Pharmacology and Physiology · 2006
    33. Hair Cycle-Specific Expression of Versican in Human Hair Follicles Journal of Dermatological Science · 2005
    34. Burden of Hair Loss: Stress and the Underestimated Psychosocial Impact of Telogen Effluvium and Androgenetic Alopecia Journal of Investigative Dermatology · 2004
    35. Molecular Biology of Hair Morphogenesis: Development and Cycling Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution · 2003
    36. Molecular Control of Epithelial-Mesenchymal Interactions During Hair Follicle Cycling ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2003
    37. Plasticity and Cytokinetic Dynamics of the Hair Follicle Mesenchyme: Implications for Hair Growth Control Journal of Investigative Dermatology · 2003
    38. Stress Inhibits Hair Growth in Mice by Inducing Premature Catagen Development and Harmful Perifollicular Inflammatory Events via Neuropeptide Substance P-Dependent Pathways American Journal of Pathology · 2003
    39. Possible Mechanisms of Miniaturization During Androgenetic Alopecia or Pattern Hair Loss Journal of The American Academy of Dermatology · 2001
    40. Efficacy and Tolerability of Hairgain in Individuals with Hair Loss: A Placebo-Controlled, Double-Blind Study Journal of International Medical Research · 2001
    41. Differences in Hair Follicle Dermal Papilla Volume Are Due to Extracellular Matrix Volume and Cell Number: Implications for the Control of Hair Follicle Size and Androgen Responses Journal of Investigative Dermatology · 1999
    42. 5α-Reductase Activity in the Human Hair Follicle Concentrates in the Dermal Papilla Archives of Dermatological Research · 1998
    43. Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia Journal of Investigative Dermatology · 1997
    44. Chronic Telogen Effluvium: Increased Scalp Hair Shedding in Middle-Aged Women Journal of The American Academy of Dermatology · 1996
    45. Chronic Telogen Effluvium Dermatologic Clinics · 1996
    46. Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells Biochemical and biophysical research communications · 1995
    47. Proteoglycans and Associated Proteins of the Mammalian Hair Follicle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1995
    48. Hair Follicle Proteoglycans Journal of Investigative Dermatology · 1993
    49. Diagnostic and Predictive Value of Horizontal Sections of Scalp Biopsy Specimens in Male Pattern Androgenetic Alopecia Journal of The American Academy of Dermatology · 1993
    50. Telogen Effluvium: New Concepts and Review Archives of Dermatology · 1993
    51. Telogen Effluvium: A Comprehensive Review Archives of Dermatology · 1993
    52. Dynamic Ultrastructural Changes of the Connective Tissue Sheath of Human Hair Follicles During the Hair Cycle Archives of Dermatological Research · 1990
    53. Rat Hair Follicle Dermal Papillae Have an Extracellular Matrix Containing Basement Membrane Components Journal of Investigative Dermatology · 1986