TLDR Decorin, a protein, may help start hair growth and could be used to treat hair loss.
The document presents a study by Jing et al. which demonstrates that decorin, a proteoglycan, is highly expressed during the anagen phase of hair follicles and decreases in expression as hair transitions from catagen to telogen, with the exception of the bulge region. The study showed that administering decorin to mice could induce an earlier onset of anagen and delay the transition to catagen, suggesting its role as a positive regulator of the hair growth cycle. These findings indicate that decorin could be a potential target for treating hair loss conditions like androgenetic alopecia by influencing androgen receptor and TGF-ß signaling pathways. The study sheds light on the potential clinical use of decorin in treating hair loss in humans.
Cited in this study
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27 citations
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March 2014 in “Experimental Dermatology” IGF-1 affects hair loss and could be a potential treatment.
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September 2013 in “Journal of Biochemistry and Molecular Biology” Androgens increase a growth factor in hair cells by creating reactive oxygen species, and antioxidants might help treat hair loss.
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September 2012 in “Experimental Dermatology” Androgens have complex effects on hair growth, promoting it in some areas but causing hair loss in others, and our understanding of this is still evolving.
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March 2012 in “Experimental Dermatology” Human hair follicles switch between active and resting phases unpredictably.
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June 2006 in “Biological & Pharmaceutical Bulletin” Androgen hormones cause hair follicle scarring in hair loss, and finasteride helps reduce it.
550 citations
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December 2005 in “The Journal of clinical investigation/The journal of clinical investigation” Researchers successfully isolated and identified key markers of stem cell-enriched human hair follicle bulge cells.
190 citations
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October 2002 in “The FASEB journal” Androgens may cause hair loss by increasing TGF-beta1 from scalp cells, which inhibits hair cell growth.