Perifollicular Fibrosis: Pathogenetic Role in Androgenetic Alopecia

January 2006 in “ Biological & Pharmaceutical Bulletin ”

Hyeon Gyun Yoo, Jin-Soo Kim, Se Rah Lee, Hyun-Mi Pyo, Hyung-In Moon, Jonghee Lee, Oh Joon Kwon, Jin Wook Chung, Se Kyu Kim, Hee Chul Eun, Kwang-Hyun Cho

perifollicular fibrosis androgenetic alopecia androgen hormones collagen follicular dermal papilla cells finasteride AGA Propecia

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Studysummary This research suggests that testosterone-induced expression of TGF-beta1 and type I procollagen may lead to perifollicular fibrosis in androgenetic alopecia, with finasteride inhibiting this process as a possible mechanism for its effects.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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Research cited in this study

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research Pathogenesis of Androgenetic Alopecia

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This article proposes three mechanisms by which dihydrotestosterone may contribute to baldness but reports no new research findings.

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This study found that canine dermal papilla cells and fibroblasts metabolize androgens differently than human hair follicle cells, indicating species-specific differences in androgen metabolism.

Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth

research Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth

190 citations , October 2002 in “The FASEB journal”

In this study, androgen did not affect keratinocyte growth in coculture with androgenetic alopecia-derived dermal papilla cells, but did significantly suppress keratinocyte growth when androgen receptor was overexpressed in the papilla cells.

research Conditional Epidermal Expression of TGFβ1 Blocks Neonatal Lethality but Causes a Reversible Hyperplasia and Alopecia

103 citations , July 2001 in “Proceedings of the National Academy of Sciences”

This study found that conditional expression of TGFβ1 in mice affects epidermal and hair follicle growth, with chronic expression causing severe alopecia and a negative feedback loop involving Smad7.

research In Vitro Main Pathways of Steroid Action in Cultured Hair Follicle Cells: Vascular Approach

30 citations , December 1999 in “Journal of Investigative Dermatology Symposium Proceedings”

This study found that in vitro treatments with 5alpha-reductase inhibitors and androgen receptor antagonists strongly stimulate VEGF expression in dermal papilla cells.

research Roles of Testosterone in the Growth of Keratinocytes Through Bald Frontal Dermal Papilla Cells

21 citations , January 1999 in “Endocrine”

research Androgen-Dependent Beard Dermal Papilla Cells Secrete Autocrine Growth Factors in Response to Testosterone Unlike Scalp Cells

51 citations , November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, researchers found that while both beard and scalp dermal papilla cells release similar autocrine growth factors, only beard cells increased production and response with testosterone, suggesting these factors enhance androgen-induced hair growth.

research Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp

227 citations , January 1998 in “Journal of Endocrinology”

This study found that dermal papilla cells from balding scalp hair follicles have significantly higher levels of androgen receptors than those from non-balding follicles, supporting their in vivo androgen response.

research Androgen Metabolism as It Affects Hair Growth in Androgenetic Alopecia

143 citations , October 1996 in “Dermatologic Clinics”

Too much androgen can cause hair loss; finasteride may help.

research Androgenetic Alopecia: An Autosomal Dominant Disorder

80 citations , January 1995 in “The American Journal of Medicine”

Hair loss in androgenetic alopecia is caused by genetic factors and androgen excess, and can be treated with combined therapies.

research Diagnostic and Predictive Value of Horizontal Sections of Scalp Biopsy Specimens in Male Pattern Androgenetic Alopecia

309 citations , May 1993 in “Journal of The American Academy of Dermatology”

This study concluded that horizontal sections of scalp biopsy specimens provide more diagnostic information for male pattern androgenetic alopecia than vertical sections and can predict hair regrowth potential following topical minoxidil therapy.

research Human Hair Growth In Vitro

385 citations , November 1990 in “Journal of Cell Science”

This study successfully grew and maintained human hair follicles in vitro, noting that TGF-β1 negatively affects growth, while EGF replicates hair-removal effects seen in animals.

research The Comparative Histopathology of Male-Pattern Baldness and Senescent Baldness

143 citations , October 1988 in “Clinics in Dermatology”

This review discusses the histopathology of male-pattern baldness and highlights ongoing disputes over several aspects, including sebaceous gland size and follicle loss, reporting no new clinical findings.

research Male Pattern Alopecia: A Histopathologic and Histochemical Study

94 citations , August 1975 in “Journal of Cutaneous Pathology”

In this study, the researchers observed that male pattern alopecia is characterized by miniature follicles, enlarged sebaceous glands, and an increased number of mast cells, without significant abnormalities in enzyme activity.