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    Perifollicular Fibrosis: Pathogenetic Role in Androgenetic Alopecia

    January 2006 in “ Biological & Pharmaceutical Bulletin ”
    Hyeon Gyun Yoo, Jin-Soo Kim, Se Rah Lee … Kwang-Hyun Cho
    Studysummary This research suggests that testosterone-induced expression of TGF-beta1 and type I procollagen may lead to perifollicular fibrosis in androgenetic alopecia, with finasteride inhibiting this process as a possible mechanism for its effects.
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    Research cited in this study 14

    1. Pathogenesis of Androgenetic Alopecia Journal of The American Academy of Dermatology · 2004
    2. In Vitro Metabolism of Dehydroepiandrosterone and Testosterone by Canine Hair Follicle Cells Veterinary Dermatology · 2004
    3. Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth ˜The œFASEB journal · 2002
    4. Conditional Epidermal Expression of TGFβ1 Blocks Neonatal Lethality but Causes a Reversible Hyperplasia and Alopecia Proceedings of the National Academy of Sciences · 2001
    5. In Vitro Main Pathways of Steroid Action in Cultured Hair Follicle Cells: Vascular Approach Journal of Investigative Dermatology Symposium Proceedings · 1999
    6. Roles of Testosterone in the Growth of Keratinocytes Through Bald Frontal Dermal Papilla Cells Endocrine · 1999
    7. Androgen-Dependent Beard Dermal Papilla Cells Secrete Autocrine Growth Factors in Response to Testosterone Unlike Scalp Cells ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998
    8. Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp Journal of Endocrinology · 1998
    9. Androgen Metabolism as It Affects Hair Growth in Androgenetic Alopecia Dermatologic Clinics · 1996
    10. Androgenetic Alopecia: An Autosomal Dominant Disorder The American Journal of Medicine · 1995
    11. Diagnostic and Predictive Value of Horizontal Sections of Scalp Biopsy Specimens in Male Pattern Androgenetic Alopecia Journal of The American Academy of Dermatology · 1993
    12. Human Hair Growth In Vitro Journal of Cell Science · 1990
    13. The Comparative Histopathology of Male-Pattern Baldness and Senescent Baldness Clinics in Dermatology · 1988
    14. Male Pattern Alopecia: A Histopathologic and Histochemical Study Journal of Cutaneous Pathology · 1975

    Related research 1

    1. Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men The Journal of Clinical Endocrinology and Metabolism · 1992