Activation of Camp Signaling in Response to Alpha-Phellandrene Promotes Vascular Endothelial Growth Factor Levels and Proliferation in Human Dermal Papilla Cells

August 2022 in “ International journal of molecular sciences ”

Won Jun Kang, Tae Sun Park, Dabin Choi, Bomin Son, Tae Sun Park

α-phellandrene cAMP vascular endothelial growth factor VEGF human dermal papilla cells DPCs cAMP/PKA/CREB pathway cAMP inhibitor alpha-phellandrene cyclic AMP

Studysummary This study demonstrated that α-phellandrene promotes dermal papilla cell proliferation through a cAMP-mediated pathway and upregulates VEGF expression, suggesting its potential use in hair loss prevention.

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The study demonstrates that α-phellandrene increases cAMP levels in human dermal papilla cells (DPCs), leading to enhanced cell proliferation and elevated vascular endothelial growth factor (VEGF) levels through the cAMP/PKA/CREB pathway. The effects were nullified by a cAMP inhibitor, confirming the pathway's role. These findings suggest that α-phellandrene could be a promising agent for promoting hair growth by enhancing DPC proliferation and VEGF production.

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