Activation of Camp Signaling in Response to Alpha-Phellandrene Promotes Vascular Endothelial Growth Factor Levels and Proliferation in Human Dermal Papilla Cells

    August 2022 in “ International journal of molecular sciences ”
    Won Jun Kang, Tae Sun Park, Dabin Choi, Bomin Son, Tae Sun Park
    TLDR α-Phellandrene may help prevent hair loss by increasing growth factors and cell growth in hair cells through a specific signaling pathway.
    The study demonstrates that α-phellandrene increases cAMP levels in human dermal papilla cells (DPCs), leading to enhanced cell proliferation and elevated vascular endothelial growth factor (VEGF) levels through the cAMP/PKA/CREB pathway. The effects were nullified by a cAMP inhibitor, confirming the pathway's role. These findings suggest that α-phellandrene could be a promising agent for promoting hair growth by enhancing DPC proliferation and VEGF production.
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