Cepharanthine Induces Proliferation of Human Dermal Papilla Cells and Stimulates Vascular Endothelial Growth Factor Expression Through Increased Intracellular Calcium Mobilization and Hypoxia-Inducible Factor Activation

December 2020 in “ Clinical and Experimental Dermatology ”

Tokuro Iwabuchi, K Ogura, Kaichiro Tamba, Yuji Tsunekawa, Masahiro Sugano, Katsuro Hagiwara, Akiko Kiso

cepharanthine human dermal papilla cells vascular endothelial growth factor intracellular calcium mobilization hypoxia-inducible factor HIF-1α HIF-2α CEP hDPCs VEGF

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Studysummary This study found that cepharanthine and its structural analogues may stimulate hair growth by promoting the proliferation of human dermal papilla cells and increasing VEGF expression in vitro.

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Research cited in this study

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research Characterization of Human Dermal Sheath Cells Reveals CD36-Expressing Perivascular Cells Associated with Capillary Blood Vessel Formation in Hair Follicles

16 citations , July 2019 in “Biochemical and Biophysical Research Communications”

This study concluded that CD36-expressing dermal sheath cells may influence the modulation of blood capillaries in hair follicles, potentially affecting hair cycling.

research Cepharanthine: An Update of Its Mode of Action, Pharmacological Properties, and Medical Applications

125 citations , May 2019 in “Phytomedicine”

This review discusses the historical development, mechanisms of action, and potential new clinical applications of the drug cepharanthine, highlighting its multi-faceted pharmacological properties; it reports no new clinical results.

research Acceleration of Hair Growth Rate by Topical Liposomal Cepharanthine in Male Androgenetic Alopecia

1 citations , January 2016 in “Hair therapy & transplantation”

In this study, male participants with early androgenetic alopecia experienced a significant increase in hair growth rate after applying topical lipoid cepharanthine lotion for six months.

Improvement of Androgenetic Alopecia with Topical Sophora Flavescens Aiton Extract, and Identification of the Two Active Compounds in the Extract That Stimulate Proliferation of Human Hair Keratinocytes

research Improvement of Androgenetic Alopecia with Topical Sophora Flavescens Aiton Extract, and Identification of the Two Active Compounds in the Extract That Stimulate Proliferation of Human Hair Keratinocytes

11 citations , October 2015 in “Clinical and Experimental Dermatology”

This study found that an extract from the root of Sophora flavescens Aiton significantly improved hair growth in patients with androgenetic alopecia over 6 months.

Induction of Insulin-Like Growth Factor-I by Cepharanthine from Dermal Papilla Cells: A Novel Potential Pathway for Hair Growth Stimulation

research Induction of Insulin-Like Growth Factor-I by Cepharanthine from Dermal Papilla Cells: A Novel Potential Pathway for Hair Growth Stimulation

13 citations , October 2013 in “The Journal of Dermatology”

This study found that topical cepharanthine increased IGF-I production in human dermal papilla cells, suggesting it may stimulate hair growth and be a promising treatment option for androgenetic alopecia.

research VEGF Induces Proliferation of Human Hair Follicle Dermal Papilla Cells Through VEGFR-2-Mediated Activation of ERK

120 citations , May 2012 in “Experimental Cell Research”

This study found that VEGF stimulates the proliferation of human hair follicle dermal papilla cells via the VEGFR-2/ERK pathway, without involving p38, JNK, or AKT signaling.

research Guidelines for the Management of Androgenetic Alopecia (2010)

38 citations , December 2011 in “Journal of Dermatology”

This article reviews current guidelines for managing androgenetic alopecia and highlights the need for guidelines tailored to Japan; it reports no new clinical results.

Minoxidil-Induced Hair Growth Is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil

research Minoxidil-Induced Hair Growth Is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil

83 citations , December 2001 in “Journal of Investigative Dermatology”

Minoxidil boosts hair growth by targeting adenosine and possibly sulfonylurea receptor 2B.

research Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis

520 citations , February 2001 in “Journal of Clinical Investigation”

This study found that VEGF significantly enhances perifollicular vascularization during the hair growth phase, accelerating hair regrowth and increasing follicle and hair size, while its inhibition retards hair growth.

research The Role of VEGF and Thrombospondins in Skin Angiogenesis

164 citations , December 2000 in “Journal of Dermatological Science”

This review explores mechanisms of skin angiogenesis and suggests targeting blood vessels as a promising therapy for skin diseases, but it reports no new research results.

research Differences in Hair Follicle Dermal Papilla Volume Are Due to Extracellular Matrix Volume and Cell Number: Implications for the Control of Hair Follicle Size and Androgen Responses

231 citations , December 1999 in “Journal of Investigative Dermatology”

This study found that the volume of a hair follicle's dermal papilla is strongly correlated with its size, primarily due to the number of cells it contains and the volume of extracellular matrix.

research Minoxidil Upregulates the Expression of Vascular Endothelial Growth Factor in Human Hair Dermal Papilla Cells

192 citations , March 1998 in “British Journal of Dermatology”

This study found that minoxidil significantly increases VEGF mRNA and protein expression in dermal papilla cells, suggesting a role in enhancing hair follicle vascularization in androgenetic alopecia.

research Bisbenzylisoquinoline Alkaloids from Stephania Cepharantha and Their Effects on Proliferation of Cultured Cells from the Murine Hair Apparatus

26 citations , October 1997 in “Planta Medica”

This study found that bisbenzylisoquinoline alkaloids from Stephania cepharantha Hayata stimulated growth in cultured murine hair cells but not in keratinocytes or fibroblasts.

A Comparison of the Culture and Growth of Dermal Papilla Cells from Hair Follicles from Non-Balding and Balding (Androgenetic Alopecia) Scalp

research A Comparison of the Culture and Growth of Dermal Papilla Cells from Hair Follicles from Non-Balding and Balding (Androgenetic Alopecia) Scalp

19 citations , March 1996 in “British Journal of Dermatology”

This study found that dermal papilla cells from balding follicles exhibit distinct growth characteristics compared to non-balding cells, suggesting their potential as a model for understanding androgenetic alopecia.

research Vascular Endothelial Growth Factor Is an Autocrine Growth Factor for Hair Dermal Papilla Cells

135 citations , January 1996 in “Journal of Investigative Dermatology”

research Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells

173 citations , July 1995 in “Biochemical and biophysical research communications”

This study suggests that IGF-I may mediate androgen-induced hair growth in outer root sheath cells cocultured with beard dermal papilla cells.

research Induction of Follicle Formation and Hair Growth by Vibrissa Dermal Papillae Implanted into Rat Ear Wounds: Vibrissa-Type Fibres Are Specified

125 citations , August 1992 in “Development”

This study found that implanting isolated adult rat dermal papillae into ear cuts led to the emergence of unusually large vibrissa-type hair follicles, demonstrating their capacity to induce specific hair fiber characteristics.

research Growth of the Hair

521 citations , January 1954 in “Physiological Reviews”

Hair growth is cyclic and influenced mainly by local factors.