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Frontline, gold standard treatment for combatting androgenic alopecia
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research Intracellular Calcium Mobilization in Response to Ion Channel Regulators via a Calcium-Induced Calcium Release Mechanism
Certain drugs increase calcium levels in cancer cells by triggering internal calcium release.
research Cepharanthine Induces Proliferation of Human Dermal Papilla Cells and Stimulates Vascular Endothelial Growth Factor Expression Through Increased Intracellular Calcium Mobilization and Hypoxia-Inducible Factor Activation
Cepharanthine (CEP), a compound derived from Stephania cephalantha, was studied for its effects on hair growth, particularly focusing on human dermal papilla cells (hDPCs). The study found that CEP and two of its structural analogues significantly promoted the proliferation of hDPCs and increased the expression of vascular endothelial growth factor (VEGF) in these cells. This effect was linked to increased intracellular calcium mobilization and activation of hypoxia-inducible factors (HIF-1α and HIF-2α), even under normal oxygen conditions. These findings suggested that CEP and its analogues could potentially aid in hair growth by enhancing hDPC proliferation and VEGF expression.
research Activation of TRPV3 Regulates Inflammatory Actions of Human Epidermal Keratinocytes
TRPV3 in skin cells causes inflammation and cell death.
research Critical Role of ATP-P2X7 Axis in UV-Induced Melanogenesis
ATP increases melanin production in skin after UV exposure, with the P2X7 receptor being crucial for this process.
research Extraskeletal Actions of Vitamin D
Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.
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5 / 8 resultscommunity Minoxidil and Caffeine - opposite effects yet comboed together?
Minoxidil and caffeine are discussed for hair loss treatment. The user questions the logic of combining them due to their opposing effects on adenosine receptors.
community How does hair loss and recovery work?
Hair loss varies due to genetic sensitivity to DHT and other factors. Treatments discussed include finasteride, minoxidil, RU58841, and microneedling.
community Caffiene shampoos left in for 2 minutes show comparable results to Minoxidil, and may work differently than Minoxidil, which can add to your stack, or work for non responders
Caffeine shampoos show comparable results to Minoxidil and may enhance its effects when used together. Caffeine can be detected in the scalp up to 24 hours after a 2-minute application, making it an affordable treatment option.
community Is hair thinning or loss associated with pain?
Hair thinning/loss associated with burning scalp pain. Finasteride helped relieve "DHT itch" for one person.
community Bloodwork reports just came in
A 21-year-old male suffering from male pattern baldness is using topical finasteride and minoxidil, and oral minoxidil. His bloodwork shows normal DHT levels and slightly high testosterone, leading to discussions about the role of DHT sensitivity in hair loss, the potential impact of finasteride on his DHT levels, and the suggestion to proceed with oral finasteride due to his high testosterone.