TLDR Calcium is important for stem cell function and maintenance, especially in blood and skin cells.
The review by Hans-Willem Snoeck from May 17, 2020, emphasizes the importance of calcium signaling in stem cell regulation, including its roles in cellular functions, metabolic and epigenetic regulation, and the complex mechanisms of calcium signaling and regulation. It specifically addresses the role of calcium in hematopoietic stem cells (HSCs) and epidermal stem cells, noting that low intracellular calcium levels are crucial for HSC maintenance and self-renewal, with studies showing a 20-fold improvement in HSC maintenance over two weeks in low calcium conditions. The calcium-sensing receptor (CaSR) is also highlighted for its role in HSC homing to the bone marrow. Additionally, a calcium gradient in the skin is important for epidermal stem cell function and skin homeostasis. The review underscores the need for further research into calcium regulation in stem cell microenvironments and its impact on stem cell function.
211 citations,
November 2018 in “Nature Cell Biology” Stem cells help heal skin wounds by moving and changing roles, working with other cells, and needing more research on their activation and behavior.
695 citations,
October 2011 in “Cell stem cell” Low oxygen areas help maintain and protect blood stem cells by using a simple sugar breakdown process for energy and managing their activity levels.
1039 citations,
February 2009 in “Nature Reviews Molecular Cell Biology” Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.
205 citations,
August 2007 in “Experimental Cell Research” Stem cell niches are crucial for regulating stem cell renewal and differentiation, and understanding them can help in developing regenerative therapies.
82 citations,
March 2016 in “Cell” The conclusion is that tissue structure is key for stem cell communication and maintaining healthy tissues.
333 citations,
February 2010 in “Cell Stem Cell” Stem cell niches are crucial for regulating stem cell behavior and tissue health, and their decline can impact aging and cancer.
11 citations,
November 2021 in “JBMR plus” The vitamin D receptor can act without its usual activating molecule, affecting hair growth and skin cancer, but its full range of actions is not well understood.
53 citations,
April 2021 in “Cell Host & Microbe” Skin bacteria, specifically Staphylococcus aureus, help in wound healing and hair growth by using IL-1β signaling. Using antibiotics on skin wounds can slow down this natural healing process.
