TLDR Stem cell niches are crucial for regulating stem cell renewal and differentiation, and understanding them can help in developing regenerative therapies.
The 2007 document reviewed the role of stem cell niches in mammals, focusing on the bone marrow, tooth, and hair follicle niches. It detailed how stem cell niches regulate the balance between self-renewal and differentiation, with the orientation of stem cell division being a key factor. The review highlighted the importance of the Notch signaling pathway and mesenchymal signals like FGF3 and FGF10 in maintaining the stem cell population in the tooth's cervical loop region. It also discussed the role of the Wnt signaling pathway and ß-catenin in hair follicle stem cell commitment, as well as the necessity of Notch1 for postnatal hair follicle maintenance, with its absence leading to hair loss. The document underscored the significance of understanding stem cell niche biology for developing regenerative therapies and the potential of targeting specific signaling pathways for tissue and organ repair, including hair.
291 citations,
October 2005 in “Proceedings of the National Academy of Sciences of the United States of America” Adult stem cells from rat whisker follicles can regenerate hair follicles and sebaceous glands.
384 citations,
June 2005 in “Genes & development” β-catenin is essential for stem cell activation and proliferation in hair follicles.
949 citations,
January 2001 in “Cell” Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.
1010 citations,
August 2000 in “Cell” Hair follicle stem cells can form both hair follicles and skin.
150 citations,
May 1993 in “The journal of cell biology/The Journal of cell biology” Mouse Notch is important for determining cell roles in hair follicles.
82 citations,
February 2017 in “Cold Spring Harbor Perspectives in Biology” The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.
39 citations,
July 2021 in “Stem Cell Research & Therapy” Using fat stem cells and blood cell-rich plasma together improves healing in diabetic wounds by affecting cell signaling.
Different stem cells are key for hair growth and health, and understanding their regulation could help treat hair loss.
Skin stem cells are crucial for maintaining and repairing skin, with potential for treating skin disorders and improving wound healing.
10 citations,
June 2016 in “Wound Repair and Regeneration” The microenvironment, especially mechanical forces, plays a crucial role in hair growth and could lead to new treatments for hair loss.
