TLDR Certain drugs increase calcium levels in cancer cells by triggering internal calcium release.
The study investigated the effects of six ion channel modulators (amiodarone, dofetilide, furosemide, minoxidil, loxapine, and Nicorandil) on intracellular calcium release in prostate and breast cancer cell lines (PC3 and MCF7). Using ratiometric calcium imaging and patch-clamp experiments, it was found that these modulators increased intracellular calcium levels in a concentration-dependent manner, similar to clinical usage levels. The increase in calcium was significantly reduced when external calcium was chelated, suggesting that these modulators mobilize intracellular calcium through a calcium-induced calcium release mechanism. This mechanism may be crucial for understanding the action of these compounds.
6 citations,
January 2016 in “Bioorganic & Medicinal Chemistry Letters” Some minoxidil combinations can help differentiate leukemia cells without harming other cells.
83 citations,
December 2001 in “Journal of Investigative Dermatology” Minoxidil boosts hair growth by targeting adenosine and possibly sulfonylurea receptor 2B.
47 citations,
October 1989 in “Circulation Research” The study explains how minoxidil sulfate causes vasodilation in rabbits by opening potassium channels and inhibiting calcium channels.
90 citations,
January 1989 in “PubMed”
January 2023 in “Dermatologic Therapy” The new 5% minoxidil foam is as effective and safe as Rogaine® for treating hair loss in Chinese men.
16 citations,
January 1995 in “Skin Pharmacology and Physiology” SEPA™ enhances the effectiveness of minoxidil in stimulating hair growth, working faster and better than Rogaine® TS, with no significant side effects.
6 citations,
July 2005 in “Farmaco” A quick and simple method was created to identify minoxidil in hair-growth products using micellar electrokinetic capillary chromatography.
1 citations,
May 2014 in “Hair transplant forum international” Rogaine can stop hair loss in women, and other treatments like certain pills, light therapy, and special shampoos may also work.
April 2011 in “The FASEB Journal” Topical Minoxidil is cost-effective for managing baldness but requires continuous use.
January 2011 in “The Internet Journal of Pharmacology” Minoxidil is cost-effective for regrowing hair on the scalp's top but not the front, requiring ongoing use.
