Vascular Endothelial Cells: Targets for Studying the Activity of Hair Follicle Cell-Produced VEGF
December 1996
in “
Cell Biology and Toxicology
”
TLDR Hair follicle cells produce VEGF, which can promote blood vessel cell growth and movement.
The study investigated the paracrine activity of vascular endothelial growth factor (VEGF) produced by hair dermal papilla cells (DPC) on fetal bovine aortic endothelial cells (FBAEC). The researchers exposed FBAEC to conditioned medium from DPC cultures and observed dose-dependent stimulation of FBAEC growth and migration. Additionally, radioreceptor assays demonstrated competitive VEGF binding in FBAEC, indicating that DPC-secreted VEGF could influence endothelial cell behavior, suggesting a role in hair follicle vascularization.
