Homozygous Whole Body Cbs Knockout in Adult Mice Features Minimal Pathology During Aging Despite Severe Homocysteinemia

    March 2022 in “ ˜The œFASEB journal ”
    Dalibor Nakládal, Sebastiaan Lambooy, Svetozár Mišúth … Leo E. Deelman
    Studysummary This study observed that mice with a whole-body deficiency of Cystathionine-β-synthase developed severe hyperhomocysteinemia and related mild symptoms without increased mortality, indicating HHCy may not directly cause end organ damage.
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    Research cited in this study 4

    1. Sebaceous Gland Abnormalities in Fatty Acyl CoA Reductase 2 (Far2) Null Mice Result in Primary Cicatricial Alopecia PloS one · 2018
    2. Enzyme Replacement Therapy Ameliorates Multiple Symptoms of Murine Homocystinuria Molecular therapy · 2017
    3. Sebaceous Gland Atrophy in Psoriasis: An Explanation for Psoriatic Alopecia? Journal of Investigative Dermatology · 2016
    4. Cystathionine Beta-Synthase-Deficient Mice Thrive on a Low-Methionine Diet ˜The œFASEB journal · 2013