PNKP Is Required for Maintaining the Integrity of Progenitor Cell Populations in Adult Mice

July 2021 in “ Life science alliance ”

Wisoo Shin, Whitney Alpaugh, Laura J Hallihan, Sarthak Sinha, Emilie Crowther, Gary R. Martin, Teresa Scheidl-Yee, Xiaoyan Yang, Grace Yoon, Taylor Goldsmith, N. Daniel Berger, Luiz Gn de Almeida, Antoine Dufour, Ina Dobrinski, Michael Weinfeld, Frank R. Jirik, Jeff Biernaskie

polynucleotide kinase phosphatase PNKP hair follicles progenitor cell populations DNA repair enzyme

Studysummary This study observed that disrupting the Pnkp gene in adult mice resulted in a premature aging-like phenotype, suggesting PNKP's vital role in maintaining normal growth and survival of certain progenitor cell populations.

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