PNKP Is Required for Maintaining the Integrity of Progenitor Cell Populations in Adult Mice

July 2021 in “ Life science alliance ”

Wisoo Shin, Whitney Alpaugh, Laura J Hallihan, Sarthak Sinha, Emilie Crowther, Gary R. Martin, Teresa Scheidl-Yee, Xiaoyan Yang, Grace Yoon, Taylor Goldsmith, N. Daniel Berger, Luiz Gn de Almeida, Antoine Dufour, Ina Dobrinski, Michael Weinfeld, Frank R. Jirik, Jeff Biernaskie

polynucleotide kinase phosphatase PNKP hair follicles progenitor cell populations DNA repair enzyme

TLDR PNKP is essential for keeping adult mouse progenitor cells healthy and growing normally.

The study investigates the role of the DNA repair enzyme polynucleotide kinase phosphatase (PNKP) in adult mice by using an inducible conditional mutagenesis approach to disrupt the Pnkp gene globally. The disruption of PNKP in adult mice led to a premature aging-like phenotype, which included impaired growth of hair follicles, seminiferous tubules, and neural progenitor cell populations. These findings suggest that PNKP is essential for maintaining the integrity and normal growth of progenitor cell populations in adult mice.

View this study on life-science-alliance.org →

Discuss this study in the Community →

Research cited in this study

8 / 8 results

research Platelet-Derived Growth Factor Signaling Modulates Adult Hair Follicle Dermal Stem Cell Maintenance and Self-Renewal

37 citations, April 2017 in “npj Regenerative Medicine”

PDGF signaling is crucial for maintaining and renewing hair follicle stem cells, which could help treat hair loss.

research Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis

242 citations, February 2016 in “Science”

Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.

research Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type

184 citations, November 2014 in “Developmental Cell”

Hair follicle dermal stem cells are key for regenerating parts of the hair follicle and determining hair type.

research Emerging Interactions Between Skin Stem Cells and Their Niches

426 citations, August 2014 in “Nature Medicine”

Skin stem cells interacting with their environment is crucial for maintaining and regenerating skin and hair, and understanding this can help develop new treatments for skin and hair disorders.

The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle

research The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle

149 citations, July 2014 in “Cold Spring Harbor Perspectives in Medicine”

The dermal papilla is crucial for hair growth and health, and understanding it could lead to new hair loss treatments.

research The Harmonies Played by TGF-β in Stem Cell Biology

156 citations, December 2012 in “Cell Stem Cell”

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

research Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss

688 citations, June 2007 in “Cell Stem Cell”

Removing the ATR gene in adult mice causes rapid aging and stem cell loss.

research Hair Follicle Pigmentation: Mechanisms and Factors Influencing Melanin Production

450 citations, January 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair color is determined by melanin produced and transferred in hair follicles.

Similar Research

5 / 31 results

research Gene Expression in Rat Dermal Papilla Cells: Analysis of 2529 ESTs

14 citations, October 2000 in “Genomics”

Rat dermal papilla cells have unique genes crucial for hair growth.

research Novel Anti-Melanogenesis Properties of Polydeoxyribonucleotide, a Popular Wound Healing Booster

18 citations, September 2016 in “International Journal of Molecular Sciences”

Polydeoxyribonucleotide (PDRN) may help lighten skin and treat hyperpigmentation.

research Annotated Patent Selections

January 2000 in “Expert Opinion on Therapeutic Patents”

The document highlights various patents for new compounds with potential treatments for multiple diseases, including cancer, hormonal disorders, and diabetes.

research Genetic Ablation of the CDP/Cux Protein C Terminus Results in Hair Cycle Defects and Reduced Male Fertility

97 citations, March 2002 in “Molecular and cellular biology”

Mutant CDP/Cux protein causes hair defects and reduced male fertility in mice.

research Promotion of Homology-Directed DNA Repair by Polyamines

47 citations, January 2019 in “Nature communications”

Polyamines help fix DNA damage accurately in cells.