Conditional Knockout in Mice Reveals the Critical Roles of Ppp2ca in Epidermis Development

    May 2016 in “ International Journal of Molecular Sciences ”
    Chao Fang, Lei Li, Jianmin Li
    Studysummary This study showed that knocking out the Ppp2ca gene in the epidermis of mice led to significant hair loss and disrupted hair follicle morphogenesis and regeneration.
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    Research cited in this study 6

    1. Cyclic Alopecia and Abnormal Epidermal Cornification in Zdhhc13-Deficient Mice Reveal the Importance of Palmitoylation in Hair and Skin Differentiation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2015
    2. Signaling Involved in Hair Follicle Morphogenesis and Development International Journal of Molecular Sciences · 2014
    3. Epidermal Development in Mammals: Key Regulators, Signals from Beneath, and Stem Cells International Journal of Molecular Sciences · 2013
    4. Development and Homeostasis of the Skin Epidermis Cold Spring Harbor perspectives in biology · 2012
    5. Conditional Activin Receptor Type 1B (Acvr1b) Knockout Mice Reveal Hair Loss Abnormality ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2010
    6. Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins ˜The œjournal of cell biology/˜The œJournal of cell biology · 1986