Conditional Knockout in Mice Reveals the Critical Roles of Ppp2ca in Epidermis Development

The study investigated the role of the α isoform of the PP2A catalytic subunit (PP2Acα) in epidermis development using Ppp2caflox/flox transgenic mice with a conditional knockout in the epidermis. The results showed that these mice experienced significant hair loss and disrupted hair follicle morphogenesis and regeneration cycles. Additionally, the mice exhibited smaller size, melanin deposition, and hyperproliferation at the base of the claws. The findings demonstrated that PP2Acα was crucial for hair follicle and epidermis development, and the transgenic mice could serve as a model for studying PP2Acα in other developmental processes and diseases.