The Notch Intracellular Domain Has an RBPj-Independent Role During Mouse Hair Follicular Development

    March 2016 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Mustafa Turkoz, R. Reid Townsend, Raphael Kopan
    Studysummary In this study, researchers observed that a noncanonical mechanism involving the γ-secretase-dependent, RBPj-independent Notch intracellular domain improves survival in Msx2-Cre mice by delaying hair follicle destruction and reducing disease severity.
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    Research cited in this study 4

    1. Notch Signaling Regulates Late-Stage Epidermal Differentiation and Maintains Postnatal Hair Cycle Homeostasis PloS one · 2011
    2. Epidermal Notch Signaling: Differentiation, Cancer, and Adhesion Current opinion in cell biology · 2008
    3. Molecular Principles of Hair Follicle Induction and Morphogenesis BioEssays · 2005
    4. Activation of the Notch Pathway in the Hair Cortex Leads to Aberrant Differentiation of the Adjacent Hair-Shaft Layers Development · 2000