Biomedical Engineering Approaches for the Delivery of JAGGED1 as a Potential Tissue Regenerative Therapy

JAG1 is a ligand crucial for activating the NOTCH signaling pathway, essential for the differentiation of mesenchymal stem cells into cardiomyocytes and cranial neural crest cells into osteoblasts, making it a promising candidate for regenerative therapies for craniofacial bone loss and myocardial infarction. However, soluble JAG1 inhibits NOTCH signaling, necessitating its immobilization within a scaffold for effective delivery. This review explores the role of JAG1 in disease, its clinical potential, and current delivery methods, comparing in vivo and in vitro models to evaluate delivery success, functional outcomes, and clinical translatability. Harnessing JAG1's ability to control cell fate could offer therapeutic benefits for various diseases.