Jagged1 and Epidermal Growth Factor Promoted Androgen-Suppressed Mouse Hair Growth In Vitro and In Vivo

    January 2020 in “ Frontiers in Pharmacology ”
    Yu‐Feng Lin, Canying Liu, Xiaoshu Zhan, Bingyun Wang, Kui Li, Julang Li
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    TLDR Jagged1 and Epidermal Growth Factor together significantly increased hair growth in mice with androgen-suppressed hair.
    In 2020, a study was conducted on 50 mice to examine the effects of Jagged1 and Epidermal Growth Factor (EGF) on androgen-suppressed hair growth. The results indicated that neither EGF nor Jagged1 alone significantly promoted hair growth. However, when combined, they significantly enhanced hair growth, improved follicle growth, increased cell proliferation in the hair follicle, and altered the expression of genes related to hair follicular cell proliferation and differentiation. In vitro results showed that hair growth significantly suppressed by testosterone was partially reversed by Jagged1 and completely reversed by EGF and the combination of EGF and Jagged1. Histological analysis showed better hair follicle development and increased follicle number with both Jagged1 and EGF. These findings suggest potential therapeutic applications of these peptides for androgenetic alopecia.
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