Jagged1 and Epidermal Growth Factor Promoted Androgen-Suppressed Mouse Hair Growth In Vitro and In Vivo

    January 2020 in “ Frontiers in Pharmacology ”
    Yu‐Feng Lin, Canying Liu, Xiaoshu Zhan … Julang Li
    Studysummary This study found that the combination of epidermal growth factor and Jagged1 significantly stimulated hair growth in mice with androgen-suppressed conditions, suggesting potential therapeutic implications for androgenetic alopecia.
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    Research cited in this study 21

    1. The Role of Extracellular Vesicles in Cutaneous Remodeling and Hair Follicle Dynamics International Journal of Molecular Sciences · 2019
    2. Hair Growth Promotion Effect of Cedrol Cream and Its Dermatopharmacokinetics RSC Advances · 2018
    3. Hair Regenerative Mechanisms of Red Ginseng Oil and Its Major Components in the Testosterone-Induced Delay of Anagen Entry in C57BL/6 Mice Molecules · 2017
    4. Epidermal Growth Factor Promotes Proliferation of Dermal Papilla Cells via Notch Signaling Pathway Biochimie · 2016
    5. Epidermal Growth Factor Promotes Proliferation and Migration of Follicular Outer Root Sheath Cells via Wnt/β-Catenin Signaling Cellular physiology and biochemistry · 2016
    6. A Comparative In Vivo and In Vitro Evaluation of Hair Growth Potential of Extracts and an Isolate from Petroleum Ether Extract of Cuscuta Reflexa Roxb Beni-Suef University Journal of Basic and Applied Sciences · 2014
    7. Signaling Involved in Hair Follicle Morphogenesis and Development International Journal of Molecular Sciences · 2014
    8. Pretreatment of Epidermal Growth Factor Promotes Primary Hair Recovery via the Dystrophic Anagen Pathway After Chemotherapy-Induced Alopecia Experimental Dermatology · 2013
    9. Androgenetic Alopecia: An Update Indian Journal of Dermatology, Venereology and Leprology · 2013
    10. Chemotherapy-Induced Alopecia Journal of the American Academy of Dermatology · 2011
    11. Ex Vivo Organ Culture of Human Hair Follicles: A Model Epithelial–Neuroectodermal–Mesenchymal Interaction System Methods in molecular biology · 2010
    12. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010
    13. Epidermal Growth Factor as a Biological Switch in Hair Growth Cycle Journal of biological chemistry/˜The œJournal of biological chemistry · 2003
    14. The Extract of Thuja Occidentalis Semen Inhibited 5α-Reductase and Androgenetic Alopecia in B6CBAF1/J Hybrid Mice Journal of dermatological science · 2003
    15. Molecular Mechanisms of Androgenetic Alopecia Experimental Gerontology · 2002
    16. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    17. Induction of the Hair Growth Phase in Postnatal Mice by Localized Transient Expression of Sonic Hedgehog Journal of Clinical Investigation · 1999
    18. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    19. Principles of Hair Cycle Control The Journal of Dermatology · 1998
    20. Specific Inhibition of Hair Follicle Formation by Epidermal Growth Factor in an Organ Culture of Developing Mouse Skin Developmental Biology · 1997
    21. Mouse Notch: Expression in Hair Follicles Correlates with Cell Fate Determination ˜The œjournal of cell biology/˜The œJournal of cell biology · 1993