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research The Notch Intracellular Domain Has an RBPj-Independent Role during Mouse Hair Follicular Development

16 citations , March 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, researchers observed that a noncanonical mechanism involving the γ-secretase-dependent, RBPj-independent Notch intracellular domain improves survival in Msx2-Cre mice by delaying hair follicle destruction and reducing disease severity.

research Genetic and molecular aspects of androgenetic alopecia

24 citations , January 2018 in “Indian Journal of Dermatology, Venereology and Leprology”

This review discusses advances in molecular biology and genetics related to androgenetic alopecia and reports no new clinical results.

research Clinical and Genetic Aspects of Alopecia Areata: A Cutting Edge Review

1 citations , June 2023 in “Genes”

This study highlights the genetic complexities in alopecia areata, emphasizing the role of microRNAs and their association with other immune-related diseases, which could inform targeted treatment strategies.

research Abstract 81

April 2017 in “Plastic and reconstructive surgery. Global open”

The researchers identified differences in gene expression between fetal and adult dermal papilla cells that could explain fetal cells' ability to regenerate hair follicles, while adult cells lack this capacity.

research 173 Impact of Clinical Severity on Absenteeism and Presenteeism in Patients with Hidradenitis Suppurativa

September 2019 in “Journal of Investigative Dermatology”

This study found that the clinical severity of hidradenitis suppurativa, evaluated through Hurley staging, VAS, PGA, and SAHS, significantly affects patients' work absenteeism and presenteeism, with presenteeism being more prevalent.

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community News on the study " Influence of Creatine Monohydrate Supplementation on Androgens and Global Hair Assessments "

12 upvotes 5 years ago

The study on creatine monohydrate's effect on hair loss was withdrawn due to lack of support. Users discussed concerns about creatine potentially accelerating hair loss, especially for those using finasteride.

community Can we trust indian medication?

8 upvotes 1 year ago

The conversation discusses the trustworthiness of Indian medications for hair loss, with some users mentioning they have purchased Minoxidil, finasteride, and RU58841 from India. Concerns include dosage and ingredient variations, but no harmful effects are noted.

community If there won't be a cure, is Manchu/Japanese rule our only option?

599 upvotes 3 months ago

The conversation humorously suggests accepting male pattern baldness by adopting historical hairstyles like those of the Manchus and Japanese, rather than hoping for a cure. It also discusses the potential of gene therapy targeting hair loss, despite skepticism about a definitive cure.

community How is there zero improvement with finding the cure?

in Research/Science 245 upvotes 7 months ago

Hair loss treatments have not advanced since 2018, with finasteride, minoxidil, and RU58841 still being the main options. A permanent cure is unlikely due to the profitability of ongoing treatments.

community Pp405 phase 2a clinical results

37 upvotes 1 year ago

PP405 shows initial promise for treating androgenetic alopecia, with safety confirmed in early trials, but skepticism remains due to limited data. Further trials are needed to determine its true efficacy and potential market impact.

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