Ppp2r2a Knockout Mice Reveal That Protein Phosphatase 2A Regulatory Subunit, PP2A-B55α, Is an Essential Regulator of Neuronal and Epidermal Embryonic Development
June 2020
in “
Frontiers in Cell and Developmental Biology
”
Ppp2r2a PP2A-B55α protein phosphatase 2A neuronal development epidermal development embryonic development syndactyly exencephaly spina bifida epidermal barrier integrity epidermal stratification protein phosphorylation signaling pathways PP2A neural development skin development embryo development webbed fingers brain protrusion spinal cord defect skin barrier integrity skin layering protein modification cell communication pathways
Studysummary This study found that the PP2A-B55α regulatory subunit is crucial for ectodermal development in mice, with knockout embryos displaying severe neural and epidermal defects and failing to survive to birth.
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