Fgf21 Deficiency Delays Hair Follicle Cycling and Modulates miRNA–Target Gene Interactions in Mice

    May 2025 in “ Biology ”
    Yana Li, Yue Ao, Xinru Xie … Xudong Guo
    Studysummary In this study, researchers found that Fgf21 knockout mice exhibited delayed hair follicle cycling compared to wild-type mice, potentially due to altered miRNA interactions affecting Vezf1 and Map3k1 expression, providing insights into the molecular regulation of hair growth.
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    Research cited in this study 11

    1. Cholesterol Promotes Hair Growth by Activating Sympathetic Nerves and Enhancing Hair Follicle Stem Cell Proliferation Molecular Medicine · 2025
    2. Regulatory Effects of FGF9 on Dermal Papilla Cell Proliferation in Small-Tailed Han Sheep Genes · 2023
    3. Hair Growth Regulation by Fibroblast Growth Factor 12 (FGF12) International Journal of Molecular Sciences · 2022
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    5. Inducing Hair Follicle Neogenesis with Secreted Proteins Enriched in Embryonic Skin Biomaterials · 2018
    6. Evaluation of Gene Expression Patterns in Micrografts Demonstrates Induction of Catagen-Like Processes During Storage Dermatologic Surgery · 2017
    7. Expression of Apoptosis-Related Genes in the Mouse Skin During the First Postnatal Catagen Stage, Focused on Localization of Bnip3L and Caspase-12 Connective tissue research · 2015
    8. Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling Seminars in Cell & Developmental Biology · 2012
    9. Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Investigative Dermatology · 2012
    10. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
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