Evaluation of Gene Expression Patterns in Micrografts Demonstrates Induction of Catagen-Like Processes During Storage
February 2017
in “
Dermatologic Surgery
”
TLDR Storing hair follicle micrografts for longer times can cause them to enter a state similar to the natural hair shedding phase, which might impact hair transplant results.
The study from February 1, 2017, examined the molecular changes in hair follicle micrografts during storage, a crucial aspect of hair restoration surgery. It was found that key gene expressions in dermal papilla cells, particularly FGF7, versican, and alkaline phosphatase (ALP), significantly decreased with longer storage times, with FGF7 becoming undetectable after 24 hours. These changes suggest that DP cells may enter a catagen-like state, which is part of the hair follicle cycle, potentially affecting the outcome of hair transplants. However, the expression of keratin genes and genes related to growth, differentiation, and apoptosis remained unchanged. The study did not specify the number of micrografts or individuals involved, which is a limitation in evaluating the robustness of the findings.
