The Intragenic mRNA-microRNA Regulatory Network During Telogen-Anagen Hair Follicle Transition in the Cashmere Goat

The document presents a study that explored the mRNA-microRNA regulatory network involved in the transition of hair follicles from the resting phase (telogen) to the growth phase (anagen) in cashmere goats. The researchers identified 12,865 differentially expressed genes and 44 differentially expressed microRNAs between the two stages. They highlighted the significance of the Wnt signaling pathway, with a function enrichment P value of 7.29E-64, and identified key genes and microRNAs, such as MiR-195, CHP1, SMAD2, FZD6, and SIAH1, that are crucial for hair follicle initiation and growth. The study, which included six cashmere goats, suggests that a complex network of gene interactions, regulated by microRNAs, controls hair follicle development. The findings could have implications for understanding the molecular mechanisms of hair growth.