Regulatory Effects of FGF9 on Dermal Papilla Cell Proliferation in Small-Tailed Han Sheep

May 2023 in “ Genes ”

Qiong Jia, Shuangshuang Zhang, Dan Wang, Jian Qiang Liu, Xinhui Luo, Li Yu, Xin Li, Feng-Yan Sun, Guangjun Xia, Lichun Zhang

Fibroblast Growth Factor 9 FGF9 hair follicle dermal papilla cell DPC Wnt/β-catenin signaling pathway cell cycle activity hair growth regulation Wnt signaling pathway hair growth

TLDR FGF9 helps hair follicles grow in small-tailed Han sheep by affecting cell growth and certain signaling pathways.

The study investigates the role of Fibroblast Growth Factor 9 (FGF9) in hair follicle (HF) growth and dermal papilla cell (DPC) proliferation in small-tailed Han sheep. FGF9 expression varies throughout the HF cycle and significantly influences wool growth. FGF9-treated DPCs exhibited increased proliferation and cell cycle activity, while FGF9 knockdown resulted in the opposite effect. Additionally, FGF9 interacts with the Wnt/β-catenin signaling pathway, suggesting it accelerates DPC proliferation and may regulate HF growth through this pathway. These findings highlight FGF9's potential in hair growth regulation and its possible use in genetically modifying sheep for improved wool production.

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