Bioinformatics Analysis of Evolutionary Characteristics and Biochemical Structure of FGF5 Gene in Sheep

    March 2019 in “ Gene
    Rui Zhang, Hongping Wu, Zhengxing Lian
    TLDR Editing the FGF5 gene in sheep increases wool length, confirming its role in hair growth.
    The study analyzed the evolutionary characteristics and biochemical structure of the FGF5 gene in sheep, revealing its phylogenetic relation to the FGF4 family and its orthology to goat FGF5. The research found that the FGF5 gene was highly conserved during evolution, with a conserved FGF superfamily domain containing 10 β-strands. The study also demonstrated that FGF5 gene editing in sheep, using CRISPR/Cas9 technology, significantly increased wool length, confirming the gene's role in hair follicle development and hair growth modulation.
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