Bioinformatics Analysis of Evolutionary Characteristics and Biochemical Structure of FGF5 Gene in Sheep

March 2019 in “ Gene ”

Rui Zhang, Hongping Wu, Zhengxing Lian

FGF5 FGF4 CRISPR/Cas9 hair follicle development hair growth modulation CRISPR

TLDR Editing the FGF5 gene in sheep increases wool length, confirming its role in hair growth.

The study analyzed the evolutionary characteristics and biochemical structure of the FGF5 gene in sheep, revealing its phylogenetic relation to the FGF4 family and its orthology to goat FGF5. The research found that the FGF5 gene was highly conserved during evolution, with a conserved FGF superfamily domain containing 10 β-strands. The study also demonstrated that FGF5 gene editing in sheep, using CRISPR/Cas9 technology, significantly increased wool length, confirming the gene's role in hair follicle development and hair growth modulation.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

11 / 11 results

research CRISPR/Cas9-Mediated Loss of FGF5 Function Increases Wool Staple Length in Sheep

47 citations , June 2017 in “The FEBS journal”

Disabling the FGF5 gene in sheep leads to longer wool.

research Analysis of the FGF Gene Family Provides Insights into Aquatic Adaptation in Cetaceans

20 citations , January 2017 in “Scientific reports”

Whale genes show changes that help them live in water, like less hair and better flippers.

research FGF5 Is a Crucial Regulator of Hair Length in Humans

136 citations , July 2014 in “Proceedings of the National Academy of Sciences of the United States of America”

FGF5 gene mutations cause unusually long eyelashes by affecting hair growth regulation.

research Hairy Tale of Signaling in Hair Follicle Development and Cycling

161 citations , August 2012 in “Seminars in cell & developmental biology”

Hair growth and development are controlled by specific signaling pathways.

research Immunohistochemical Localization of Fibroblast Growth Factor 18 in Hair Follicles of Healthy Beagle Dogs

2 citations , March 2011 in “Veterinary Dermatology”

FGF18 is present in beagle dog hair follicles, mainly in the inner root sheath.

research KGF And EGF Signaling Block Hair Follicle Induction And Promote Interfollicular Epidermal Fate In Developing Mouse Skin

82 citations , May 2009 in “Development”

EGF and KGF signalling prevent hair follicle formation and promote skin cell development in mice.

research The Hair Follicle as a Dynamic Mini-Organ

759 citations , February 2009 in “Current Biology”

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

research Four Independent Mutations in the Feline Fibroblast Growth Factor 5 Gene Determine the Long-Haired Phenotype in Domestic Cats

75 citations , September 2007 in “Journal of Heredity”

FGF5 gene mutations cause long hair in domestic cats.

research Adenosine Stimulates Fibroblast Growth Factor-7 Gene Expression Via Adenosine A2b Receptor Signaling in Dermal Papilla Cells

66 citations , February 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Adenosine may promote hair growth by increasing FGF-7 levels in dermal papilla cells.

research The Long And The Short Of It: Evidence That FGF5 Is A Major Determinant Of Canine Hair-Itability

73 citations , June 2006 in “Animal genetics”

The FGF5 gene determines hair length in dogs.

research Biology of the Hair Follicle: The Basics

224 citations , March 2006 in “Seminars in Cutaneous Medicine and Surgery”

The document concludes that understanding hair follicle biology can lead to better hair loss treatments.

Similar Research

5 / 414 results

Bioinformatics Analysis of Evolutionary Characteristics and Biochemical Structure of FGF5 Gene in Sheep

Research cited in this study

research CRISPR/Cas9-Mediated Loss of FGF5 Function Increases Wool Staple Length in Sheep

research Analysis of the FGF Gene Family Provides Insights into Aquatic Adaptation in Cetaceans

research FGF5 Is a Crucial Regulator of Hair Length in Humans

research Hairy Tale of Signaling in Hair Follicle Development and Cycling

research Immunohistochemical Localization of Fibroblast Growth Factor 18 in Hair Follicles of Healthy Beagle Dogs

research KGF And EGF Signaling Block Hair Follicle Induction And Promote Interfollicular Epidermal Fate In Developing Mouse Skin

research The Hair Follicle as a Dynamic Mini-Organ

research Four Independent Mutations in the Feline Fibroblast Growth Factor 5 Gene Determine the Long-Haired Phenotype in Domestic Cats

research Adenosine Stimulates Fibroblast Growth Factor-7 Gene Expression Via Adenosine A2b Receptor Signaling in Dermal Papilla Cells

research The Long And The Short Of It: Evidence That FGF5 Is A Major Determinant Of Canine Hair-Itability

research Biology of the Hair Follicle: The Basics

Related Community Posts Join

community Mystery compound found to be safe and effective at treating hair loss. Details in comments.

community DIY treatment... Shedding completely stopped after 1.5 yrs

community Sanguisorba Officinalis Root Extract, and other FGF-5 inhibitors?

Similar Research

research Recent Advances in the Role of Fibroblast Growth Factors in Hair Follicle Growth

research Fgf21 Deficiency Delays Hair Follicle Cycling and Modulates miRNA–Target Gene Interactions in Mice

research Hair of the Dog: Identification of a Cis-Regulatory Module Predicted to Influence Canine Coat Composition

research Molecular Regulatory Mechanisms in Chicken Feather Follicle Morphogenesis

research FGF Family: From Drug Development to Clinical Application