CRISPR/Cas9-Mediated Loss of FGF5 Function Increases Wool Staple Length in Sheep

    June 2017 in “ ˜The œFEBS journal ”
    Wen Rong Li, Chen Xi Liu, Xue Mei Zhang … Ming Jun Liu
    Studysummary This study found that CRISPR/Cas9-induced loss-of-function mutations in the FGF5 gene significantly increased wool length and yield in genetically modified Chinese Merino sheep compared to wild-type controls.
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    Research cited in this study 8

    1. Disruption of FGF5 in Cashmere Goats Using CRISPR/Cas9 Results in More Secondary Hair Follicles and Longer Fibers PLoS ONE · 2016
    2. Fibroblast Growth Factor 5-Short (FGF5s) Inhibits the Activity of FGF5 in Primary and Secondary Hair Follicle Dermal Papilla Cells of Cashmere Goats Gene · 2015
    3. Molecular Cloning, Characterization, and Expression of Sheep FGF5 Gene Gene · 2014
    4. FGF5 Is a Crucial Regulator of Hair Length in Humans Proceedings of the National Academy of Sciences of the United States of America · 2014
    5. The Long And The Short Of It: Evidence That FGF5 Is A Major Determinant Of Canine Hair-Itability Animal genetics · 2006
    6. Hair-Cycle-Dependent Expression of Parathyroid Hormone-Related Protein and Its Type I Receptor: Evidence for Regulation at the Anagen to Catagen Transition ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2003
    7. Manipulation of Outer Root Sheath Cell Survival Perturbs the Hair-Growth Cycle The EMBO Journal · 1999
    8. The Role of Keratin Proteins and Their Genes in the Growth, Structure, and Properties of Hair Birkhäuser Basel eBooks · 1997