Hair Growth Regulation by Fibroblast Growth Factor 12 (FGF12)

August 2022 in “ International Journal of Molecular Sciences ”

Jiwon Woo, Wonhee Suh, Jong‐Hyuk Sung

Fibroblast Growth Factor 12 FGF12 outer root sheath cells ORS cells anagen phase telogen phase hair follicles hair growth growth factors hair loss therapy growth phase resting phase hair loss treatment

Studysummary In this study, FGF12 was found to promote hair growth in mice by inducing the anagen phase of hair follicles, suggesting potential for hair loss therapy. Our plain-language summary of this paper — not a Tressless recommendation.

The study "Hair Growth Regulation by Fibroblast Growth Factor 12 (FGF12)" found that FGF12, primarily expressed in outer root sheath (ORS) cells during the anagen phase of hair follicles, plays a significant role in hair growth. When FGF12 expression was reduced in mice, it delayed the transition from the telogen (resting) phase to the anagen (growth) phase and decreased hair length. However, overexpression of FGF12 promoted the migration of ORS cells, induced the transition from the telogen to anagen phase, and upregulated various growth factors related to hair growth. The study suggests that FGF12 could be a potential target in hair loss therapy. The study involved 5 mice for in vivo experiments and 3-15 samples for in vitro experiments.

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