Chrysanthemum Zawadskii Extract Induces Hair Growth by Stimulating the Proliferation and Differentiation of Hair Matrix

The study demonstrated that Chrysanthemum zawadskii extract (CZe) promoted hair growth by stimulating the proliferation and differentiation of hair matrix cells. Using n-butanol and water fractions of CZe on C57BL/6 mice for 30 days, researchers found that the water fraction induced premature entry of hair follicles into the anagen phase and increased hair shaft production. Immunohistochemical analysis revealed that CZe stimulated pluripotent epidermal matrix cells and epithelial stem cells. Flavonoids were identified as the active constituents, suggesting that the water fraction of CZe could be developed as a therapeutic agent for preventing hair loss.