Logic-Based Modeling and Drug Repurposing for the Prediction of Novel Therapeutic Targets and Combination Regimens Against E2F1-Driven Melanoma Progression

    November 2023 in “ BMC chemistry ”
    Nivedita Singh, Faiz M. Khan, Lakshmi Bala … Satish Gupta
    Studysummary In this study, researchers used computational modeling and virtual screening to identify two FDA-approved drugs, Tadalafil and Finasteride, that may effectively inhibit key proteins involved in melanoma progression, suggesting potential for new therapeutic strategies against aggressive melanoma.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on bmcchem.biomedcentral.com →
    Discuss this study in the Community →

    Research cited in this study 3

    1. Finasteride Inhibits Melanogenesis Through Regulation of the Adenylate Cyclase in Melanocytes and Melanoma Cells Archives of Pharmacal Research · 2018
    2. Self-Microemulsifying Systems of Finasteride with Enhanced Oral Bioavailability: Multivariate Statistical Evaluation, Characterization, Spray-Drying and In Vivo Studies in Human Volunteers Nanomedicine · 2015
    3. Reply to Finasteride and Dutasteride May Reduce Melanoma Risk Cancer · 2015